Despite healing, brain retains sensitivity: This article explores the topic in depth.
Therefore,
Despite healing. Consequently, brain retains sensitivity:
Essential
- Compared to healthy people, patients with recurring depression, but healed, show significantly increased activation of the bilateral habit, which treats negative experiences.
- In addition. For example, they have a decreased functional connectivity between the Hardenula and the Ventral Tegmental Area, an important nucleus of the mesencephalon responsible for the production of dopamine. In addition,
- These data could make it possible to better identify people at risk of relapse. Therefore, develop more targeted interventions to treat and prevent future depressive episodes. Therefore,
Up to 80 % of people with depression have a recurrence of symptoms within five years. In a new research. published in the journal Biological Psychiatry : Cognitive Neuroscience and Neuroimagingresearchers from the Radboud University Medical Center (Netherlands) have tried to better understand despite healing, brain retains sensitivity the underlying mechanisms that contribute to the vulnerability of a relapse patient. In order to carry out the study. the authors analyzed the functional MRI data of 36 adults with recurring depression and 27 healthy people.
Habenula, a brain area dealing with negative experiences
The objective? Evaluate brain activity during a so -called aversive learning task. This is“A type of classic Pavlovian packaging where a person learns to avoid a stimulus. behavior by associating them with an unpleasant outcome.” During the intervention, the participants learned associations between an image and an unpleasant bitter taste. By examining the scanners. the team focused on the Hardenula, a small region of the brain involved in the treatment of negative experiments, to determine if the anomalies of this system persist even after the healing of depressive symptoms.

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Depression: continuous brain processes make patients despite healing, brain retains sensitivity vulnerable to future episodes
According to the results, the volunteers healed from a depressed disorder presented an increased activity of the Hardenula, in particular in anticipation of an unpleasant outcome. The latter had a reduced connectivity between the Habenula. the Ventral Tegmental Area, an important nucleus of the me utécaphale responsible for the production of dopamine (a neurotransmitter linked to the reward) and an area supposedly regulated by the activity of the Habenula. These patterns suggest increased sensitivity to negative signals. reduced capacity to regulate responses to potential punishment, even after the disappearance of symptoms.

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“Understanding these persistent effects could make it possible to better identify people at risk and develop more targeted interventions to improve long -term recovery and prevent future depressive episodes.”
despite healing, brain retains sensitivity
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