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A major scientific advance could transform the treatment of diabetes. Thanks to an international team of scientists, human pancreatic islets have been printed in 3D, potentially capable of reducing dependence on insulin injections. This advance uses an innovative bio-enacle that simulates the natural environment of the pancreas, thus opening the way to more effective and less invasive treatments for millions of people with type 1 diabetes in the world.
The revolutionary bio-impression process
The team of researchers, led by Dr. Quentin Perrier, has developed an innovative method to print in 3D of pancreatic islets. Using a special bio-en accre composed of alginate and decellularized human pancreatic tissue, they managed to create a structural support that imitates the pancreas. This technique allows islets to receive oxygen and nutrients necessary for their survival. The precise settings of the 3D printer, including a low pressure of 30 kpa and a slow printing speed of 20 mm per minute, made it possible to minimize physical stress on the islets, thus retaining their natural shape.
Laboratory tests have shown that these bio-printed islets remain viable and functional, with a cell survival rate above 90 %. This advance demonstrates their clinical potential, as cells react better to glucose, thus releasing more insulin when necessary. This step represents significant progress towards personalized treatments for diabetes.
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“Intelligent” islands for effective treatment
After 21 days, islets showed an increased capacity to detect and react to blood sugar levels. This performance could be attributed to their porous architecture, which facilitates the flow of oxygen and nutrients, while promoting vascularization, essential to their long -term survival and functionality after transplantation. This is one of the first studies to use real human islets instead of animal cells in bio-impression, which constitutes promising progress.
Currently, the team tests these structures in animal models and explores long -term storage options, such as cryoprevation, in order to make this therapy accessible to the greatest number. They also seek to adapt their method for other sources of insulin producing cells, including those derived from stem cells and xeno -îlots from pigs.
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Towards the end of insulin injections?
This advance could one day eliminate the need for insulin injections for people with type 1. diabetes. According to Dr. Perrier, the aim is to recreate the natural environment of the pancreas to improve the survival and functionality of transplanted cells. The current trials could lead to tailor -made implantable therapy, thus transforming the treatment and quality of life of millions of people.
The potential of this technology lies in its ability to provide ready -to -use treatment for diabetes. If clinical trials confirm its effectiveness, this could revolutionize the way in which diabetes is treated today, offering a viable and less invasive alternative to current insulin treatments.
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Remaining challenges and future prospects
Although this innovation marks a significant step forward, several challenges remain to be met before this technology is widely available. Clinical trials must still confirm the efficiency and safety of these bio-printed islands in humans. Large -scale production and regulation issues must also be addressed to ensure global access to this therapy.
Research continues to explore solutions to overcome the shortages of donors, in particular by the use of stem cells and xeno -îlots. Efforts are also focused on optimizing storage and transport methods to ensure that the islets remain viable until they are located in the patient. What other technological progress could emerge from this research to further improve the treatment of diabetes?
The author relied on artificial intelligence to enrich this article.
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