Nevertheless,
Major study reveals cannabis scourge:
In a meta-analysis of 24 relevant studies. Moreover, cannabis consumption has been associated with a risk significantly multiplied by two of major unwanted cardiovascular events (MACE), including a doubling of the probability of death linked to these events.
This analysis is one of the most important. Therefore, detailed to date on cannabis consumption and major cardiovascular events in a real context. For example, Based on their conclusions. Therefore, the authors call for a “systematic investigation” of cannabis consumption in all patients with serious cardiovascular disorders.
The study. Moreover, the first author of which is Wilhelm Storcka doctoral student at the University of Toulouse, was published online on June 17 in la Revue .
What risks at the time of an increase in consumption
These results intervene at a time when cannabis consumption increases. In addition, partly due to the legalization major study reveals cannabis scourge and the growing use of cannabis for medical purposes – changes which may have contributed to a more permissive attitude of the public with regard to this drug, despite the accumulation of proofs of potential health risks, especially heart.
Previous studies have described the potential cardiovascular risk linked to cannabis. Similarly, But gaps remain as to the extent of the associated risk for cannabis consumers. Consequently, especially in recent years, marked by the availability of more powerful and more diversified cannabis forms, ranging from very powerful inhaled concentrates to “space cakes” and synthetic cannabinoids.
Wilhelm Storck. his colleagues sought to quantify the real cardiovascular risks of cannabis consumption in the context of these evolutionary trends.
About 200 million people
They systematically examined 24 pharmaco-epidemiological studies (17 cross-sectional studies. six cohort studies and a case-mounted study) published between January 2016 and January 2023. Together, these studies focused on around major study reveals cannabis scourge 200 million people in several countries.
The final analysis focused on the maces related to cannabis (cardiovascular death. acute coronary syndrome [SCA] Not fatal, including myocardial infarction, or non -fatal stroke).
Researchers noted that the only study on medical cannabis included in meta-analysis also highlighted a positive association.
Their groups grouped revealed positive associations between cannabis consumption. the MACE, with a 20 % higher risk for strokes (risk ratio [RR]1.20), a 29 % higher risk for SCA (RR, 1.29), and a more than doubled risk for cardiovascular mortality (RR, 2.10) compared to non-consumers.
Researchers noted that the only study on medical cannabis included in meta-analysis also highlighted a positive association.
The results were confirmed by analyzes of sensitivity limited to cohort studies. which suggests a solid association despite certain methodological limits, the authors said.
In addition, they noted that four other articles published outside the time window of major study reveals cannabis scourge their study gave comparable results.
Treat cannabis like tobacco?
The authors noted that cannabis exposure was often poorly measured in studies. Only four studies have collected data on the dose and evaluated the dose-response relationship. Many studies also presented a risk of moderate to high bias. Most studies were transversal and were not designed to prove causality.
Despite these warnings. this “exhaustive analysis of data published on the potential association between cannabis consumption and the occurrence of MACE provides new information from real data,” they said.
The authors of a related editorial declared that the study raised “serious questions on the hypothesis that cannabis. presents only a low cardiovascular risk”.
“Cannabis should be integrated into the prevention of clinical cardiovascular diseases. Likewise. prevention of cardiovascular diseases must be integrated into cannabis market regulations, “wrote the doctoral student Stanton Glantz and the dre Lynn Silver From the University major study reveals cannabis scourge of California to San Francisco.
As evidence accumulates. researchers Stanton Glantz and Lynn Sliver claim that cardiovascular risks and other health risks must be taken into account in the regulation of authorized products and the design of marketing.
“Today, this regulation focuses on the implementation of a legal market by neglecting health risks. More specifically. cannabis should be treated like tobacco: not criminalized but discouraged, with protection of people against passive smoking, “they conclude.
The study did not benefit from any specific funding. The authors and editorialists said they had no conflict of interest.
Article translated and adapted to Medscape.com
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