However,
New genetic study reveals why:
It is a reality: some people age better than others.
A certain ease in the 90s with the mind. Nevertheless, the body intact, while others struggle against diabetes, Alzheimer’s disease or the mobility of decades earlier. Therefore, Some may withstand a bad fall or counter-grippius with ease, while others never leave the hospital again.
New research led by Boulder of the University of Colorado. Nevertheless, published this month in the journal Genetics of nature, Shed light on the reason why it is.
In this document, an international team of co-authors identifies more than 400 genes associated with accelerated aging on seven different subtypes. Meanwhile, The study reveals that different groups of genes underlie different types of disorderly aging. Similarly, alias fragility, ranging from cognitive decline to mobility problems to social isolation.
The new genetic study reveals why results support what is called “the hypothesis of geoscience”-the idea that to treat the multiple chronic diseases that accompany aging. Consequently, we must treat aging itself.
To be able to identify the treatments to stop. Similarly, reverse accelerated biological aging, you should know what is the underlying biology. However, This is the biggest study to use genetics to try to do so. Therefore, “”
Isabelle Foote, first author on the article and postdoctoral researcher at the Institute of CU Behavioral
Redefine “fragility”
The study focuses on “fragility”, a catch-all term for the “multi-on-the-back decline” which often comes with aging.
Over 40% of American adults over 65 are considered fragile.
Doctors generally evaluate fragility using an index of 30 points which measures things such as walking speed. strength of adhesion, the number of diagnosed diseases and the amount of social activity. The problem. said Foote, new genetic study reveals why is that two people can get the same high fragility score even if you are cognitively sharp but cannot work and another is in good physical health but has a bad memory.
This lack of distinction has made it difficult for doctors to make recommendations. scientists to determine the underlying causes of unhealthy aging.
“Aging is not just a thing. There are many ways to be fragile, “said Dr. Kenneth Rockwood, a leading expert in fragility, based at Dalhousie University in Nova Scotia, Canada and co-author of the study. “The question then becomes: which genes are involved? »»
To find out. the team conducted an “Association Study at the Genome scale” analyzing DNA and health information of hundreds of thousands of participants in British biobank and other public data sets to see which genes were associated with 30 symptoms of fragility.
They identified 408 genes associated with accelerated aging / new genetic study reveals why fragility, a significant increase compared to the 37 genes previously identified.
Some genes. they noted, were strongly linked to certain unhealthy aging subtypes, notably: “handicap”; “Poor cognition”; “Metabolic problems”; “Several diseases”; “Generally an unhealthy way of life”; and “limited social support”.
For example. the SP1 gene, associated with immune function and Alzheimer’s disease was strongly associated with the “bad cognition” subtype, while the FTO gene, a gene known to be associated with obesity, seemed underlying several different categories of unhealthy aging.
“What this document is doing is not only identifying the disorderly aging sub-factors. but there is also that there is a very different biology that underpins them,” said the main author Andrew Grotzinger, deputy professor of psychology and neuroscience in Cu Boulder. “The next tangible step is to understand how to treat this underlying biology. »»
New genetic study reveals why
An anti-aging pill?
In the short term. the authors new genetic study reveals why suggest that the clinical measures of fragility which often manifest well before specific diseases are not extended to include the six subtypes.
In this way. a person diagnosed as a cognitive fragile could be guided towards therapies to prevent dementia, while a fragile person in the metabolic field could take measures to prevent diabetes or heart disease.
Fote envisages one day when people could get a “polygenic risk score” offering a more detailed overview of the. unhealthy aging type to which they are subject.
But the Holy Grail. she says, would be to identify the molecular pathways which push aging itself and develop therapies to put the brakes.
Is a single anti-aging pill on the horizon?
Unlikely.
But could there be one day a pill to deal with a set of age-related metabolic problems. and another to solve many cognitive problems?
It’s an enticing idea, said Grotzinger.
“This document suggests new genetic study reveals why that it will probably not be a single magic pill to approach all the diseases that come with aging. but perhaps it does not need to be hundreds. »»
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