Adding new benzodiazepines of summary on the list of psychotropic substances

The National Agency for the Safety of Medicines. Therefore, Health Products (ANSM) classifies new Benzodiazepines of Synthesis (also called “Benzodiazepines designer” or D-BZD) on the list of psychotropic drugs. Consequently, These substances have more powerful effects than those of drugs containing benzodiazepines. For example, Their use exposes to risks of dependence and death in the event of overdose.

Synthetic benzodiazepines (also called “benzodiazepine designer”. However, D-BZD or synthetic analogous of non-pharmaceutical benzodiazepines) are “new synthetic products” (or NPS) with the chemical structure and the pharmacological effects of benzodiazepines. They are illegal and generally sold on the internet in various forms (blotters, liquids, powders, tablets). They are used in particular to reduce anxiety, such as sedative or in combination with other drugs.

In 2018, the ANSM had classified some of these benzodiazepines of summary on the list of psychotropic substances. However. the adding new benzodiazepines summary list number of addictovigilance reports linked to the summary benzodiazepines continues to increase and new molecules of this class have been identified in the territory.

Due to health risks: risks of abuse. dependence and overdose, as well as their circulation in the territory, the ANSM class 9 new substances: production, sale and use are prohibited in France, from 07/10/2025.

The 9 Benzodiazepines of summary added to the list of psychotropic substances:

• Bentazépam.
• Bromonordiazepam (Synonym Disalkylgidazépam);
• Flubrotisol;
• Fluclootizolam;
• Gidazépam;
• methylclonazepam;
• Norflurazepam (synonym Norfludiazepam or Disalkylflurazepam);
• Tionordazépam (Synonyme déméthylsulazépam);
• Tofisopam (Synonyme in Emandaxin).

Indeed. the power of action of these benzodiazepines of synthesis means that they can cause serious effects for health, even in very low doses : severe sedation (drowsiness to coma), confusion, agitation, alteration of memory, balance and coordination disorders, difficulties in breathing. These side effects can last for several days. The risk of potentially fatal adding new benzodiazepines summary list overdose (overdose) is also very high.

These molecules are generally used at low doses, which can make them difficult to detect in the blood. In addition. they are often overlooked and therefore not detected during biological analyzes, exposing consumers to a delay in care during hospitalization or in case of overdose.

Information pour les professionnels de santé
Si un patient présente une altération de la conscience. une hypotonie et une dépression respiratoire sans signe évocateur d’intoxication opioïde, il peut s’agir d’une intoxication aux benzodiazépines de synthèse. Ces molécules sont généralement utilisées à faible dose, ce qui les rend difficilement détectables.
En cas de suspicion de surdosage ou d’intoxication. le flumazénil, antagoniste des benzodiazépines, permet d’annuler les effets des benzodiazépines de synthèse tels que coma et dépression respiratoire, confirmant ainsi la présence de benzodiazépines.
Concernant l’identification des produits ainsi que la prise en charge des usagers concernés. vous pouvez contacter le CEIP-A ainsi adding new benzodiazepines summary list que le centre antipoison de votre région.
L’analyse du produit consommé peut être réalisée notamment via le dispositif SINTES (Système d’identification national des toxiques et des substances). de l’Observatoire français des drogues et des tendances addictives.