Consequently,
Autism: major discovery reveals four:
To achieve these conclusions. In addition, American researchers from Flatiron Institute and Princeton University have analyzed clinical and genetic data in detail 5,392 autistic children from the American cohort Spark, as well as those of 1,972 of their non -autistic brothers and sisters.
The goal was to better understand why children diagnosed with autistic people have such varied profiles. Similarly, Scientists have analyzed 239 Characteristics for each participant. Meanwhile, ranging from social interactions to repetitive behaviorpassing through cognitive disordersl’Age of the first words and psychiatric diagnostics Associated, before applying an advanced statistical method to identify homogeneous subgroups.
Four biological profiles identified in autistic children – Autism: major discovery reveals four
Result. However, autism appears as a mosaic of four distinct biological profiles, each characterized by Specific symptoms et Different genetic causes. However, This classification contributes to explaining why children carrying a same diagnosis can present very different life courses. Consequently,
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autism: major discovery reveals four
- The first group, baptized “Social/Behavioral Challenges”brings together about 37 % of children studied. It is characterized by marked difficulties in social interactions et repetitive behavioroften associated with disorders such as anxiety. Furthermore, hyperactivity, but without a significant delay in engine or language development. The researchers have identified that the genetic alterations concerned act mainly after birth.
- The second group, “Mixed ASD with Developmental Delay”concerns near 19 % of children. This profile combines the classic signs of theautism has A global delay in developmentwith a later acquisition of walking. language. Here, the genetic variations observed are mainly inherited and active from prenatal life.
- The third group, “Moderate Challenges”, Groups approximately 34 % of childrenwith more moderate manifestations of the disorder, little psychiatric comorbiditiesengine and language development in general normal and more diffuse genetic alterations.
- Finally, the fourth group, called “Broadly Affected”represent approximately 10 % of the sample. It includes children with autism: major discovery reveals four severe and multiple disorders, including Cognitive, motors and behavioral deficits. This profile is linked to so -called novo genetic mutations, which appeared spontaneously, without being transmitted by the parents.

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Different genetic causes depending on the profiles
The study also reveals that these profiles differ at the moment when genetic anomalies influence the brain development : Some before birth, others after. This temporal distinction makes it possible to better understand the diversity of trajectories observed in Autistic children.
A major advance for personalized medicine
These results pave the way for a new approach to diagnostic and the care. Researchers believe that better knowledge of Biological autism subtypes will allow you to refine Therapeutic interventions Taking into account. the specificities of each profile. Validated in A second independent cohortthis classification is today one of the most precise. solid descriptions of the heterogeneity of theautism. This scientific advance could lay the foundations autism: major discovery reveals four for a more personalized medicine at the service of children. underline the authors of the study.
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Autism: major discovery reveals four
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