Calvitie – A gel tested in humans triggers a real regrowth: “This treatment has produced real hair, not down”

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Calvitie – gel tested humans:

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Illustration: Application of topical treatment on a striking area of the scalp – a gesture similar to that used in clinical trials of the PP405 molecule developed in UCLA.

© Helena Nechaeva

The subject returns every year as a slightly mocking chestnut: “Soon a remedy for baldness?”. Meanwhile, But in the shadow of miracle shampoos and hair implants, serious research was calvitie – gel tested humans advancing. For example, Today. Consequently, it is a UCLA laboratory that comes out of the wood with a concrete announcement: a molecule, PP405, triggered a real regrowth of hair during clinical trials. Therefore, A first that could well mark a turning point.

Pp405: the molecule that could (finally) tackle baldness

Battled people have seen it pass, “revolutions” announced with drums and trumpets … to often finish powder in the eyes. But this time. the announcement comes from a laboratory of UCLA University, in the United States, and it is based on concrete results: a molecule called PP405 could well allow millions of skulls bare to regain natural hair.

We have shown that it is possible to restart hair growth with topical calvitie – gel tested humans treatment. by reactivating stem cells without the need for invasive interventions.

William Lowry, professor of molecular biology in UCLA

How ? By directly reactivating dormant stem cells in the hair follicles, these mini-organizations that produce the hair. A function that the molecule seems capable of relaunching, at least partially, in humans. And without surgery or injection: PP405 is in the form of a gel, to be applied simply to the scalp.

The first clinical results, carried out on 78 participants, are deemed very encouraging. In eight weeks, 31 % of patients saw their hair density increase by more than 20 %. These are not fishing hairs, but real hair, according to the researchers. Admittedly, it does not work on everyone, but the approach is well documented, well tolerated, and technically promising.

No treatment will work for everyone. but our first trials on calvitie – gel tested humans humans conducted in the County of Orange are very encouraging, and others, on a larger scale, are to come […] Obtaining the FDA authorizations always takes time, and that’s normal. But it will be worth waiting.

William Lowry, professor at UCLA

Pelage pharmaceuticals, the start-up from the UCLA lab, is already preparing the rest. If the next steps confirm these results. a phase 3 could open in 2026, with the (undefined) objective of a marketing by the end of the decade.

So no, it’s not yet the end of baldness. But for the first time for a long time, it is no longer a joke either.

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Calvitie – gel tested humans

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