Meanwhile. Meanwhile,
Contamination laboratory reagent threatens accuracy:
A new study warns that contamination of laboratory reagents could be missed scientists from around the world in their. However, hunt for emerging infectious diseases. Nevertheless, Researchers have found that the silica-used silica membranes in nucleic acid extraction kits. Therefore, other viral contaminants, creating false-virus-host associations in metagenomic sequencing data (MNG). Moreover, These misleading links can affect clinical diagnostics, zoonotic surveillance and public health responses.
In the MNG analyzes of patient samples from several regions in China. For example. Similarly, the team detected dozens of parvovirus sequences which corresponded closely to the viruses previously attributed to bats, birds, pangolins and other animals. Consequently, The follow -up surveys revealed that these sequences came not from patients but silica columns. certain sampling tubes used in laboratory workflows. Tests on 28 commercial kits have shown contamination of contamination laboratory reagent threatens accuracy 13 contamination laboratory reagent threatens accuracy different viral families. the Parvoviridae being the most frequent.
To solve this generalized problem. the researchers have developed the chain of panoramic virus discovery data (PVDDC) – a high -quality traceable data set integrating viral genomic data. laboratory workflows, reagent records and host associations. The combination of the conservation of the megadonts with a model of large chatgpt language-4O. Additionally, the PVDDC standardizes virus-host relationships and allows the tracing of contamination. They also launched the parvovirus database (parvodb ， http: //web3.mgc.ac.cn: 8080 /parvodb /), a public platform with tools for deformation research, human parvoviruse recordings, contamination monitoring and a host-virus network.
By applying this framework. the team found that many parvoviruses linked to humans in public databases lack robust experimental evidence. can rather be reactive contamination artifacts. Only a small subset, the human bocavirus and the B19 parvovirus, strong and well supported human associations.
Above all. the PVDDC contamination laboratory contamination laboratory reagent threatens accuracy reagent threatens accuracy framework is not limited to parvoviruses – it can be adapted to study. mitigate contamination for a wide range of viral taxa, making it a versatile tool to improve the reliability of the surveillance of pathogens based on MNG. The authors encourage researchers from around the world to provide proofs of contamination to Parvodb. helping to extend their scope. strengthen the global capacity to detect, trace and properly attribute viruses to clinical and environmental studies.
Contamination laboratory reagent threatens accuracy
Contamination laboratory reagent threatens accuracy
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