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Cpads allows complete analysis drug:
The CPADs integrate data from the gene expression omnibus (GEO). Meanwhile, the cancer genome atlas (TCGA) and the sensitivity to drug sensitivity in cancer databases (GDSC), encompassing more than 29,000 samples through 44 types of cancer and involving 288 drugs. Nevertheless, It provides five main analysis modules: analysis of differential expression, correlation analysis, path analysis, drug analysis and gene disturbance analysis. In addition, These modules allow users to explore changes in gene expression. Consequently, correlations between genes or medicines, tracking the way, sensitivity to drugs and the impact of genetic disturbances on resistance to drugs.
The differential expression analysis module allows users to compare gene expression levels between witness. Meanwhile, drug -processed groups or between medication and resistant groups. Similarly, The correlation analysis module supports the unique. multigenous correlation study studies, revealing cpads allows complete analysis drug how the expression of genes is correlated with the IC50 medication values. The analysis of the tracks is facilitated by the analysis of enrichment of the genes of genes (GSEA). the enrichment analysis of the unique gene (SSGSEA) set and a sample sample (SSGSEA), allowing users to explore the enrichment of specific tracks in samples treated with the drug. Additionally, The drug analysis module examines the relationship between gene expression. IC50 medication values, helping to identify potential drug resistance markers. Finally, the gene disturbance analysis module operates GPSADB and CGP data to detect genes associated with drug resistance.
The article highlights the case study of the L1CAM as a potential target of drug resistance in lung cancer. non -small cells (CNPNC). Thanks to the GSEA enrichment analysis. the study identified the positive regulation of L1CAM in samples treated with cisplatin, suggesting its role in resistance to drugs. A more in cpads allows complete analysis drug -depth analysis of CPADs has confirmed that the expression of L1CAM was significantly associated with resistance to cisplatin. potentially with resistance to other drugs such as bosutinib and rapamycin.
CPADS stands out for other web tools due to its extensive data set, large sample size and versatile analytical capacities. It offers customizable visualizations and detailed directives, which makes it accessible to users without programming expertise. The tool is designed to evolve with the integration of new data sets. advanced analytical methods, aimed at becoming a complete resource for Pancancer pharmacogenomic research.
Cpads allows complete analysis drug
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