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Dementia -type protein bubbing cancer:
Scientists funded in the United Kingdom have discovered dementia type behavior in pancreas cells at risk of transforming cancer. Meanwhile, The results provide clues that could help treatment. Nevertheless, prevention of pancreatic cancer, a difficult disease to be treated linked to 6,900 deaths in the United Kingdom each year.
Research was published today (August 15) in the journal Development unitand was funded by Cancer Research UK. Consequently, with additional Wellcoma support, the Medical research advice and Biotechnology and Biological Sciences Research Council.
Researchers from Cancer Research UK Scotland Center have studied pancreatic cells in mice over time. However, to see what caused healthy cells in cancer cells. Moreover, They discovered that pancreatic cells at risk of becoming cancerous. In addition, called pre-cancer, develop defects in the cell recycling process (called “autophagy”).
In dementia -type protein bubbing cancer pre-cancer cells, researchers have noticed excessive molecules of “problem proteins” forming clusters-behavior observed in neurological diseases such as dementia. Consequently, Researchers have also noticed similar fronting in human pancreatic samples. In addition, which suggests that this happens during the development of pancreatic cancer.
Cancer Research UK Fellow at the University of Edinburgh University Institute. Nevertheless, Professor Simon Wilkinson, said:
“Our research shows the potential role of the role that the disturbance of autophagy plays in the beginnings of pancreatic cancer. Although the early stage. we can potentially learn research on other diseases where we see agglomeration proteins, such as dementia, to better understand this type of aggressive cancer and how to prevent it. »»
Although survival for many types of cancer has improved in recent decades. this has not been the case for pancreatic cancer. This is partly because it is often diagnosed at an advanced stage, where treatment options dementia -type protein bubbing cancer are limited. To remedy it, the researchers wanted to know more about what could cause cancer of pancreatic cells.
Several types of cancer. including pancreatic cancer, are linked to a defective mutation in a gene called Kras, but scientists are learning more and more that genetic changes are not the whole history.
One of the ways that cells keep healthy people is to break excessive molecules they no longer need. thanks to a recycling process called “autophagy”. Autophagy is particularly important in the pancreas to control the level of digestive proteins. hormones that the pancreas produces to help decompose food.
Scientists have studied autophagy in detail for many years. learn the key role it plays in diseases such as cancer. In some cases. cancer cells can become “dependent” of autophagy, by diverting the recycling process to help cancer cells to divide and develop more quickly.
This research. on the other dementia -type protein bubbing cancer hand, suggests that the combined effect of the defective kras gene and disturbed autophagy could be the development of pancreatic cancer. Researchers plan to study these processes in more detail. to see if they can help predict or possibly reverse the start of pancreatic cancer, and if factors such as age, sex or diet play a role.
About 10. 500 people receive a diagnosis of pancreatic cancer in the United Kingdom each year and, unfortunately, too many of these cases are at a stage where the processing options are limited. Although additional work is necessary. these results could provide vital indices on how we can better understand how pancreatic cancer develops. »»
Dr Iain Foulkes, Executive Director of Research and Innovation at Cancer Research UK
One of the main priorities in Research UK cancer is research on pancreatic cancer. We finance research on the dementia -type protein bubbing cancer causes of pancreatic cancer. tests to diagnose the disease and clinical trials designed to seek improvement of treatment, reduce side effects and symptom control.
The article, entitled “Er-Phagy and Proteostase Defects Defects Defects of Pancreatic Epithelial State Prim Development unit.
Dementia -type protein bubbing cancer
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