Effective GLP-1 analogues in the treatment of addiction

The analogues of GLP-1. Similarly, used in the treatment of diabetes and obesity, have shown some effectiveness in the treatment of addiction, especially to alcohol

Now consumed by millions of people around the world, the analogues of GLP-1, including the famous semaglutide (Ozempic and Wegovy), which became “stars” drugs, have revolutionized the treatment of diabetes and obesity. Therefore, Several studies have demonstrated their potential efficiency for several other pathologies such as Parkinson’s disease or Alzheimer’s disease. For example, It seems that these “miracles” molecules could also have beneficial effects in the treatment of addiction.

It is almost by chance that Danish researchers (countries from which Novo Nordisk is from. Nevertheless, the laboratory which markets the Ozempic) discovered the potential of A-GLP-1 in the treatment of addiction. Meanwhile, They observed that wealthy patients who followed treatment with A-GLP-1. who used to tour wines in France or Italy effective glp-1 analogues treatment addiction had lost much interest in alcohol consumption.

Semaglutide is the most effective A-GLP-1 in the treatment of alcohol addiction

As of 2013. it has been shown that the consumption of exenatide, the first A-GLP-1 marketed in the world (which is produced from the saliva of the Gila monster, a lizard in the American desert), led, in an animal model, to a drop in the consumption of alcohol and cocaine. The cessation of exénatide treatment is almost immediately ending the consumption of consumption of psychoactive products.

The study was reproduced by Professor Anders Fink-Jeansen teams in vervets. monkeys found in particular in the Antilles and which are known for their high appetite for alcohol (and who do not hesitate to steal the drinks of little attentive tourists). Again, a drop in alcohol consumption was observed with exenatide but also with another A-GLP-1, Liraglutide.

Professor Fink-Jeansen teams then continued their studies in humans with alcohol effective glp-1 analogues treatment addiction use disorder to whom they administered semaglutide. The study made it possible to highlight an important point: the semaglutide is much more effective in reducing alcohol consumption in obese. overweight people than in individuals with normal weight. The impact is felt as much in the amount of alcohol consumed as in the number of days when. the individual drinks in large quantities.

Also effective against other psychoactive substances?

Studies on animals. humans show that semaglutide is more effective than exenatide to reduce alcohol consumption in people with alcohol -related disorders. Other studies suggest that semaglutide also reduces the consumption of cannabis and opioids.

Finally. a retrospective study conducted last year by the National Institutes of Health (NIH) and which followed nearly 600,000 patients with type 2 diabetes concluded that semaglutide leads to a reduction of more than 50 % of disorders linked to the use of alcohol within 12 months, compared to effective glp-1 analogues treatment addiction other antidiabetic treatments.