FODMAP diet with low repair of the fleeing intestines in IBS-D patients

In a study. Meanwhile, patients with irritable colon syndrome suffering from diarrhea, or IBS-D, which followed a weak FODMAP diet saw an improvement in the dysfunction of the colonic barrier, commonly called “intestine that fled”. Meanwhile,

The results. Therefore, published in Gastroenterologyrepresent the first proof of the low potential FodMAP capacity to improve intestinal permeability and activation of mastocytes in patients with SCI. For example,

It is believed that the diet. Consequently, the microbiome were linked to the fleeing intestine, but the reasons why were not well understood.

This research sheds light on the mechanism of how food can interact with the intestinal microbiome. Consequently, the intestinal immune system to influence the malfunction of the colonic barrier and validate the low Fodmap diet as a treatment option which not fodmap diet low repair fleeing only improves symptoms but the underlying dysfunction in the SCI. For example, »»

Prashant Singh, MBBS, Michigan Medicine gastroenterologist and principal author on the newspaper

The low FODMAP diet is a proven intervention for patients with SCI.

Most people with IBS report symptoms triggered by food and prefer food inventions to pharmacotherapy.

The fleeing intestine refers to the symptoms caused by increased permeability of the intestinal lining.

It is believed that this permeability has a variety of negative consequences. in particular the dissemination of toxins and bacterial products as well as the awareness of local nerves which can cause pain in the SCI.

The researchers studied human patients to test the potential of a weak FODMAP to approach the fleeing intestine. while the mice treated with stools of these patients were used to study the mechanisms of the way the food potentially improves fodmap diet low repair fleeing the colonic barrier.

Forty-eight patients with IBS-D (Irritable colon syndrome with diarrhea) were placed on a low-level FODMAP diet (restriction phase). supplied with low FODMAP meals for the duration of the study.

Of the 42 participants to complete the study. 34 responded to the low Fodmap diet, which all experienced reduced diarrhea and abdominal pain.

Previous studies have shown that patients with IBS-D have increased the number of mastocytes (type of inflammatory cell in the colon lining). the fleeing intestine.

Studies have shown that mastocytes are also more likely to be activated in IBS-D.

In this study. the function of barrier and the activation of mastocytes were evaluated in various ways before and after the period of four weeks. Additionally,

The researchers found that in addition to improving the fleeing intestine. a low FODMAP also reduced the number and activation of mastocytes in the lining of the colon fodmap diet low repair fleeing in these patients.

Researchers also worked on an explanation for how the weak FODMAP improves the fleeing intestine (and how a diet. rich in FodMap food can contribute to the barrier dysfunction.)

Lipopolysaccharides are molecules derived from the intestinal microbiome which can cause responses from the immune system when they escape. the intestine.

In this latest study. an analysis using mice, researchers have shown that the high FODMAP diet in IBS-D patients increases fecal LPS levels to activate mastocytes which in turn make the barrier more flight.

Given these results. researchers recommend that suppliers consider mastocyte stabilizers in addition to a low FODMAP diet-or as an alternative to low FODMAP diet when it is contraindicated.

“Our study shows that the diet is not a rapid solution – this is a real solution for some patients with SCI. ” said Singh.

The authors hope that future studies will include a larger fodmap diet low repair fleeing sample size. in particular patients who do not respond to the low Fodmap diet, and a variety of IBS types in addition to IBS-D.