Genetic risk of depression linked to the response of the mute brain to victories and losses

New imaging research indicates that young adults with higher genetic risk of depression showed less brain activity in several areas when they respond to rewards. Meanwhile, punishment. For example, The study also revealed notable differences between men and women. Meanwhile, The results of this new study in Biological psychiatry: cognitive neuroscience. Furthermore, neuroimageryPosted by Elsevier, highlight the first potential depression indicators before the clinical symptoms that are fully manifested.

Depression is one of the most common mental health problems. Similarly, and many people suffering from depression have trouble dealing with rewards and punishments. However, We know that genetics plays a role in depression. but it is not yet clear how genetic risk could affect the brain’s response to positive and negative experiences. Researchers from this study explored this link in young adults genetic risk depression linked response before the symptoms of fully developed depression.

In one of the first studies aimed at showing how the genetic risk of depression could affect the way the brain reacts to good. bad results in daily decision -making, researchers explored how neuronal markers of the treatment of reward and punishment reflect the overall genetic risk of depression, if these markers are distinct from those associated with the seriousness of depression, and if men and women differences in these genetically lit markers.

“The emphasis on the study on individuals who are not yet diagnosed with depression are paving the way to a better understanding of how the genetic predisposition interacts with brain function in the context of reward. punishment, opening up new avenues for early detection and targeted therapies for depression,” comments the head editor of the head the chie Biological psychiatry: cognitive neuroscience and neuroimagery Cameron S. Carter, MD, University of genetic risk depression linked response California Irvine.

The researchers evaluated the brain scanners of the functional MRI. the genotyping data of nearly 900 twins or brothers and sisters in good health (22 to 35 years) in the Human Connectome (HCP) project while they were playing a game of play that involved earning or losing money. They examined how the participants’ brain reacted during victories. losses, and how it was linked to their genetic risk of depression.

The main researcher Chiang-Shan R. Li. MD, PHD, Department of Psychiatry and the Department of Neuroscience, the Yale University neuroscience program, and the Institute of Inter-Leappage Neuroscience, the University of Yale, “we have found that individuals with higher genetic risk of depression have shown less activities in brain areas related to attention and decision-making, The punishment, at the pundière, to the bread and to the punctual way and to the occipital Occipation. The cingular cortex was strongly associated with genetic risk depression linked response punishment but not with award.

This research shows that the genetic risk of depression can quietly influence the reaction of the brain to daily rewards. setbacks – even before someone feels depressed. These first cerebral markers could help us detect who is in danger. find better ways to intervene before the appearance of symptoms. The differences between identified sexes make this work exceptionally appropriate, while the field moves to more personalized mental health care. “”

Yu chan, phd, Main author of the article, Department of Psychiatry, Medicine School of the University of Yale