How probiotics could limit the damage caused by pesticides, according to scientists

Until now. Moreover. In addition, the digestive flora was considered more or less pronounced alterations, but a recent study by Jiangjiang Zhu and his team, published in Nature Communications, reverses this observation. However, For the first time. Moreover, the effects of eighteen agricultural pesticides commonly used were mapped out of seventeen major species of microbiota bacteria. Consequently, This work. Therefore. Similarly, supported by the “National Institute of General Medical Sciences”And fruit of international collaboration associating, in particular, Yu Wang (Johns Hopkins University), Caroline Johnson (Yale University) and researchers from Zhejiang Academy In Hangzhou (China), opens a new era in understanding the interactions between chemical toxicity and biological balance.

The results are worrying: many pesticides alter bacterial growth, disrupt metabolic mechanisms and accumulate within organisms. However. However. Nevertheless, an unexpected discovery offers a glimmer of hope: certain bacteria how probiotics could limit damage new would be able to degrade these toxic substances, paving the way how probiotics could limit damage for innovative strategies to protect the health. In addition. Similarly, In particular, the experiment on mouse with Bacteroides ovatus has shown a significant reduction in inflammation induced by agricultural pollutants. Despite the gradual prohibition of certain pesticides in Europe, their persistence in food makes targeted interventions (probiotics, food hygiene, etc.) to preserve the fragile balance of the human microbiota.

Probiotics: a new hope against the damage of pesticides – How probiotics could limit damage new

For several years. the scientific community has been alarmed by the deleterious effects of pesticides on the Intestinal microbiota and. by ricochet, on the human health. Intestinal bacteria play a key role in digestion, energy production and immune modulation. However, even prohibited molecules continue to unbalance the microbial flora, with potential long -term consequences. According to Jiangjiang Zhu’s study at “The Ohio State University“. Substances such as glyphosate how probiotics could limit damage new or certain insecticides alter the growth of bacteria such as bifidobacteria or Escherichia coli.

The most striking disturbances how probiotics could limit damage affect the capacity of certain bacteria to metabolize. store pesticides, resulting in a decrease in the production of metabolites essential, in particular lipids. Ces Metabolic alterations influence:

• Immunity regulation. the response to infections.
• Inflammation control systemic and local in the intestine;
• Oxidative stress balancekey factor in cellular aging;
• Nutrient assimilation essential to health.

Faced with this challenge, Zhu’s team has shown that certain stumps of probioticsas Bacteroides ovatuscan alleviate these harmful effects. Mouse tests show that targeted supplementation significantly reduces inflammatory markers and normalizes disturbed metabolic profiles. Consequently. regular consumption of probiotics (via yogurt, kefir or specific supplements) appears to be a concrete track to support individual health.

• Integrate fermented foods (Natural yogurt. Kimchi. Miso, Kombucha) to your daily diet;
• Consult experts Before choosing a probiotic complement, each strain with specific effects;
• Wash carefully Fruits how probiotics could limit damage new and vegetables to reduce pesticide residues;
• Vary your diet In order to promote the diversity of intestinal bacteria.

New molecular atlas: towards targeted probiotic interventions

The how probiotics could limit damage major contribution of themolecular atlas élaboré par l’équipe. de Jiangjiang Zhu (Li Chen. Chao Guo. Huan Zhang, Shiqi Zhang, Andrew Gold, Ming Hu, Dayong Wu, Hong Yan, Shanshan Di, Xinquan Wang) réside dans sa précision. Fruit de l’analyse more than 10. 000 samplesthis work goes well beyond descriptive studies: it details the effects of each pesticide on each key species. of the microbiota.

The methodology combined:

• Culture in vitro 17 major species of bacteria exposed to 18 agricultural pesticides.
• Metabolomic analysis high resolution to identify the compounds from the bacteria – pesticide interaction.
• In vivo experiments On mice, in order to assess digestive and systemic repercussions, in particular inflammation.

These investigations have revealed that certain bacteria massively accumulate pesticides, altering the structure of their membranes how probiotics could limit damage new and their metabolic profiles. On the other hand. several species (including Bacteroides ovatus) have the ability to degrade. eliminate these substances, opening the way to microbial treatments of how probiotics could limit damage detoxification Targeted after exhibition.

Among the most striking results: mice exposed to realistic doses of pesticides have an increase in inflammatory markers. metabolic anomalies, while recolonization with ovatus bacteroides in significantly reduces impact, especially on lipid pathways.

• Identification of microbes capable of degrading certain pesticideslimiting their intestinal toxicity.
• Perspective d’interventions “post-exposition” based on suitable probiotics;
• Provision of public data To accelerate research on disease -related diseases.

This new scientific tool. the fruit of a collaboration between “The Ohio State University”the “Zhejiang Academy” in China. several international partners, offers a unique basis for deciphering the interaction mechanisms between pesticides et microbiota. It inaugurates a research dynamic focused on precision and intervention, capable of transforming preventive practices into public health.

• Exploit the molecular atlas how probiotics could limit damage new to guide new studies on contaminated foods.
• Sensitize the population to the importance of preserving the diversity of microbiota through food and lifestyle.

The challenge of the next decade is launched: transforming these how probiotics could limit damage innovative scientific advances into concrete. practices to permanently protect human. health in the face of the increasing pressure of pesticides in our diet.

References:

• https://www.nature.com/articles/s41467-024-48904-y
• https://academic.oup.com/femsre/article/46/2/fuab056/6517452