New research reveals a great influence of B vitamins on health and disease

Eight essential nutrients constitute the continuation of B vitamins also known as complex B. Meanwhile, Researchers from TUFTS University. Furthermore, elsewhere have revealed that these B vitamins influence a large spectrum of health and human disease, in particular cognitive function, cardiovascular health, gastric bridging recovery, defects of neural tube and even cancer.

“It is difficult to study vitamins B isolated. Furthermore, ” explains gastroenterologist Joel Mason, main scientist of Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) and professor at Gerald J. Additionally, Furthermore, and Dorothy R. For example, Friedman School of Nutrition Science and Policy and Tufts University School of Medicine. Therefore, “Four of these B vitamins cooperate as co-factor in many critical activities in cells in what we call” a. In addition, carbon metabolism “. Similarly, »»

A new research reveals great influence carbon metabolism is a series of routes that allow the transfer of single carbon units to cells for essential processes such as DNA synthesis. Nevertheless, amino acid metabolism, etc. Nevertheless, It is their role in all these crucial biological functions that make B vitamins so important. For example, so difficult to reveal how they contribute positively and, perhaps negatively, to human health.

Mason. In addition, two other researchers who have spent their careers studying one or more of the B vitamins explain what we currently know about the impact of the five of the most sought -after vitamins or improve cognitive and cardiovascular health.

Cognitive health, b₁₂et folate

One of the most active areas for vitamin research B is cognitive health. However, At the age of 75 to 80, 40% of people have a decrease in the ability to absorb B.₁₂said Mason. Furthermore, This deficiency leads to new research reveals great influence a drop in nervous health. Nevertheless, especially in the spine and the brain, which can contribute to the risk of developing dementia in the elderly. Nevertheless,

For decades, clinicians and researchers have thought of measuring plasma B₁₂ was precise enough to determine if supplementation was necessary. However. For example, says Mason, while many elderly people can have b₁₂ Levels found in the “low to normal” range, they simultaneously develop neurological deficits linked to vitamin B₁₂ deficiency. Consequently,

The contribution of vitamin B₁₂ Cognitive declining deficiency. Nevertheless, vascular diseases which leads to many cases of dementia is underdiagnosed and under-declared. However, “”

Irwin H. Moreover, Rosenberg. Therefore, professor emeritus of Jean Mayer University, Tufts University

Rosenberg is also a former dean of the Friedman School of Nutrition Science and Policy who also taught pharmacology at the School of Medicine. Nevertheless,

“The age -related new research reveals great influence cognitive decline is not only Alzheimer’s disease,” says Rosenberg. “We have gathered many types of brain dysfunction under a single name. And in doing so. we have ignored the way in which critical blood vessels – and by extension, nutrition is to preserve the brain function. »»

The pathology of Alzheimer’s disease has described the abnormal accumulation of two proteins in the amyloid brain. the tau that come together together, forming plates and tangles that disturb the function of brain cells.

However. Rosenberg claims that cerebrovascular diseases and small vessel disease, which are in some cases linked to vitamins B deficiency, is more widespread with cognitive decline and dementia than the accumulation of harmful proteins in the brain, which was the objective of so much research and drug development to treat Alzheimer’s disease. Treating people with medication intended to approach protein accumulation will not work if the cause of new research reveals great influence dementia symptoms is. a b₁₂ deficiency.

Tests to determine if the cognitive symptoms of decline. dementia can be caused by a B₁₂ The deficiency is therefore imperative, he said.

« B₁₂ The tests measure all B₁₂ In your system. even if about 80% are inactive, “said Paul Jacques, HNRCA principal scientist and professor at the Friedman School of Nutrition Science and Policy.

To identify a B₁₂ The deficiency requires two additional tests. One, called MMA test, measures methymalonic acid levels, an acid produced in certain aspects of metabolism requiring an adequate B₁₂. “It can be high with even a light B₁₂ deficiency, indicating a higher potential risk of dementia, ”explains Jacques.

A second test measures the levels of an amino acid, homocysteine, which is also a by-product of metabolism requiring B₁₂. If only homocysteine levels are high, a folate deficiency can be the problem. If MMA and homocysteine are high, AB_{12 new research reveals great influence} The deficiency is the probable culprit.

If a patient has neurological problems. signs of dementia, the realization of the three tests will shrink if a vitamin B deficiency is involved and which vitamin B is.

“Contrary to the changes that we are unable to see in patients who receive expensive anti-amyloid antibodies to treat Alzheimer’s disease. there are in fact proven that early enough in the course of cognitive decline, we can slow the process if the underlying cause is homocysteine or B₁₂-The linked can, “explains Rosenberg. It is my recommendation that patients. with or without anemia, should be detected for high homocysteine or B₁₂ Security because this can be one of the reversible factors of their cognitive decline. “”

This is not a new theory. Two decades ago. studies like Framingham Heart Study showed that high homocysteine predicts brain atrophy and a higher risk of dementia. More recently. new research reveals great influence trials such as Vitacog and Fact have shown that vitamin B supplementation can slow brain narrowing and improve cognitive performance in people at risk.

“There is a huge amount of education necessary around this problem,” explains Rosenberg. “We hope to convince cardiologists. neurologists and internists to measure B₁₂ and homocysteine levels as part of the evaluation of cognitive disorders. Even the modest effects of vitamins that cost the cents per day can be very significant in those who benefit from it. especially when you compare vitamins supplementation to expensive drugs that receive much more attention for the same or less advantage. “”

New research reveals great influence

B₁₂ and dementia

Jacques. his colleagues are currently directing a study using data of around 2,500 adults of middle ages and older in the study by Framingham Heart, who were all exempt from dementia in the 1990s and all received new research reveals great influence B₁₂MMA and homocysteine tests in the past 20 years.

“The risk of dementia. Alzheimer at a late stage begins to increase when you are 75 or over, but the evidence suggests that some of the pathological changes associated with dementia and Alzheimer’s can start to develop more than 20 years before clinical symptoms and diagnosis,” explains Jacques. “This study should give us a good command of the question of whether B₁₂ is linked to cognitive decline. dementia. If this is the case. I hope that we can identify a simple and inexpensive intervention which could be launched years in advance and before real damage occurred. “”

Jacques also plans the role of Folat (B₉) can play in the development of cognitive problems. in particular the influence of the high folate levels could have on B₁₂ and cognitive health.

In the 1950s, people with anemia were treated with folic acid, new research reveals great influence the synthetic form of the Folate. Unfortunately. it has become clear that even if a pharmaceutical treatment with folic acid attenuated anemia, he often masked or exacerbated B₁₂ deficiency. “Scientists have observed that people with low B₁₂ And high concentrations of folic acid tended to have cognitive problems. “explains Jacques.

More recent research has suggested that it was not total B₁₂ Concentrations that folic acid could affect. but perhaps a single component, Holotc, which is the form of vitamin B₁₂ It is crucial for the transport and use of B₁₂ in cells and is considered a potentially better indicator of vitamin B₁₂ Status.

Jacques and his colleagues carry out two studies to tease the problems concerned. “In the first. our aging study in vitamin and the brain, we will examine the influence on the status of high folate on the relations between B₁₂ and cognitive health. A second study new research reveals great influence that we do in collaboration with Rutgers will examine the effect of folic acid raised in the blood on the two forms of B₁₂ -Holotc. unrelated Cobalamine. “”

New research reveals great influence

Heart disease. cholesterol and stroke

Vitamins B have also aroused the excitation of researchers because of their possible role in the prevention of heart disease and cerebral vascular accidents, but so far, their usefulness as a clinical treatment remains limited.

Scientists discovered in the early 2000s that Riboflavin (B₂) could decrease blood pressure very effectively. It is believed that riboflavin improves a biochemical reaction mediated by a gene called MTHFR (methylènetrahydrofolate reductase) which helps. the body to use the folate. Riboflavin is only effective in reducing blood pressure specifically in patients with the MTHFR 677 TT genotype.

Vitamines B₆B₁₂And the Folate helps the body to get rid of homocysteine. which, in overabundance, had been new research reveals great influence linked to an increased risk of heart attacks and strokes, as well as dementia. However. a number of clinical trials in the 1980s showed that B₆B₁₂And folate supplementation has not reduced heart attacks, but slightly reduced the risk of cerebral vascular accidents.

Niacine (b₃) can reduce LDL (the so-called “bad cholesterol”) and raise HDL (the so-called “good cholesterol”). “But it is necessary to take in such important doses that it often causes a very uncomfortable rinsing. like hot flashes,” explains Mason. “People can often not tolerate it. and other drug options are available that reduce LDL Bloods which have no unpleasant side effects. »»

Chronic inflammation. B₆

Perhaps the most promising for the future is the role of vitamin B₆ Can play in the reduction of inflammation, which has been identified as an underlying characteristic of many chronic diseases, from heart disease to diabetes through dementia arthritis.

new research reveals great influence

A certain number of animal studies, as well as certain human studies, suggest that the additional b₆ can reduce inflammation. “Once again. we are talking about giving B vitamins to an appropriate pharmaceutical level in the care of a clinician,” warns Mason. “B₆ can be toxic in large quantities. “He considers this research as an area to look at in the years to come.