Meanwhile,
Novo melanoma associated naevus do:
An Australian prospective study reveals that melanomas on naevus (24 % of cases) have a. Similarly, separate risk profile. Meanwhile, Their location varies according to sex, directing towards personalized monitoring and screening strategies.
Skin melanoma can occur again or appear on a preexisting naevus, phenomenon called by Anglo-Saxons naevus-associated melanomaor Nam. Consequently, It was suspected. Nevertheless, thanks to epidemiological studies often of case-controlle or retrospective type, that the risk factors differ for these two types of melanomas whose development mechanisms may not be similar. Similarly,
In an attempt to provide answers to these questions. However, by freeing oneself from the limits of previous studies, CM olsen et al. In Australia undertook a prospective study on a large cohort in Queensland. Similarly, A total of 43,794 adults aged 40 to 69 were recruited on the Queensland electoral lists of 2010-2011. In addition,
Participants completed a self-questionnaire novo melanoma associated naevus do on their demographic characteristics. their skin type, their conduct in the face of solar exposure and the history of sunburns, especially in childhood, their medical history and in particular the treatments received for skin cancer.
The analysis was restricted to people with European ancestors. Moreover. participants who have suffered from an invasive melanoma or on-site Were excluded to avoid any bias of detection linked to narrower medical supervision.
After various other exclusions (missing data) there were 38,801 participants, including 17,752 men and 21,049 women.
Information on all diagnostics of melanomas that occurred in this cohort between 2011. December 31, 2022 was obtained thanks to the Queensland cancer register. Anatomopathology reports have been reviewed to specify the existence of a possible association with a preexisting naevus. Melanoma diagnoses revealed by the presence of metastases were excluded.
A polygenic risk score was calculated for 15,687 participants whose genotype was able to establish.
Much novo melanoma associated naevus do more naevus and not quite the same locations in case of NAM
During median monitoring of 11.4 years (11.2 to 11.7), invasive melanomas were diagnosed in 859 participants: 209 (24.3 %) were NAM (129 men and 80 women) and 650 (75.7 %) were melanoma again (362 men and 288 women). For people who have had several melanomas during the follow-up (n = 71) these successive tumors tended to be of the same type. that is to say NAM or again.
Men presented NAM (61.7 %) a little more often than melanomas again (55.7 %) and NAMs affected a little younger subjects (average age 62.8 years for NAM versus 64.9 years for melanoma again). The average thickness of the NAM (Breslow index) was less (0.58 mm vs 1.02 mm for melanoma again). Finally the NAM were more often SSM type (Superficial Spreading Melanoma ; 65.1 %) and more rarely LMM type (Lenitgo novo melanoma associated naevus do Malone Melaman ; 3.8 %) that melanoma again (56.7 % and 30.8 % respectively).
The location would also differ between Nam and Melanoma againthe firstly touching the trunk more (53.6 % vs 30.9 %) while melanoma again were more often on the head and neck and upper limbs.
It is still necessary to specify a variation according to sex: predominance of NAM on the trunk for men. on the upper and lower limbs for women.
Risk profiles (age. sex, phototypes, solar exposure, family history) were generally identical for the two types of NAM melanomas and again. However. we note that the association with a great “density” of Naevus is statistically greater and significant for the NAM (Hazard Ratio for several naevus vs No naevus = 6.86; 95 % confidence interval [IC 95 %] 3,83-12,33 vs 3,21 [2,23-4,63] For melanoma again.) Likewise the association with a high melanoma -high polygenic risk score novo melanoma associated naevus do was more marked for NAMs than for melanomas again.
This large prospective study with a follow -up of more than ten years therefore found a rate of 24. % of melanomas associated with naevus. A large number of naevus. a high polygenic risk score appeared as the only risk factors having a more significant effect (Hazard Ratio) on the risk of NAM than on the risk of melanoma again. The preferential location of NAM on the trunk or members suggests a greater impact of intermittent solar exposure. A concept to consider for the monitoring of patients with a large number of naevus!
Novo melanoma associated naevus do
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