In addition,
Nudibranches (sea slugs) emerge promising new: In addition,
Nudibranches (sea slugs) emerge promising:
Sea slugs in bright colors could contain the key to cancer treatments of tomorrow, with their derivative and self -taught chemicals that have shown powerful tumor capacities.
Review: Nudibranches as sources of natural marine products with anti -tumor activity: a complete review. Similarly. Furthermore, Image credit: Sakis Lazarides / Shutterstock
In a recent study published in the journal Marine drugsResearchers in Spain have examined the bioactive potential of nudibranchs derived from compounds. For example, emphasizing their anti -tumor properties.
Background – Nudibranches (sea slugs) emerge promising – Nudibranches (sea slugs) emerge promising new
Cancer is among the main causes of mortality and morbidity. Furthermore, In 2022, 20 million cancer diagnoses and 9.7 million cancer nudibranches (sea slugs) emerge promising deaths were recorded. In addition, 30% of premature nudibranches (sea slugs) emerge promising new deaths in people aged 30 to 69 were due to cancer. However, Thus, it is essential to increase existing treatments or to develop new therapies. However, The search for new drugs focused on natural resources, extending to the oceans.
Marine organizations have adapted to extreme conditions, leading to the production of secondary metabolites with high bioactivity. In addition. Furthermore. Similarly, marine metabolites have more halogen atoms, longer carbon chains and larger rings of rings with less oxygen and more nitrogen atoms than land metabolites.
To date. Meanwhile. Moreover, more than twenty drugs derived from the navy have been approved by the US Food and Drug Administration, many of which are for the treatment of cancer. However. Nevertheless. Similarly, these often face limitations such as resistance to drugs and a lack of selectivity, highlighting the need for continuous bioprospection. Nevertheless, Nudibranches are a group of marine nudibranches (sea slugs) emerge promising nudibranches (sea slugs) emerge promising new gastropod molluscs with around 4,700 species.
Due to the absence of an external shell. In addition. However, other physical defenses, nudibranchs have unique chemical defense strategies, involving the synthesis of novo of bioactive metabolites or the accumulation and modification of toxins and secondary food compounds, which are often concentrated in accessible tissues such as the coat or dorsal extensions called Ceron.
In this study. Therefore, researchers have examined the potential of nudibranchs as a source of natural marine products with anti -tumor properties.
Nudibranches and their antitumoral potential
Nudibranches have become promising candidates for new pharmacological agents for cancer treatment. Studies have identified numerous secondary metabolites in nudibranchs which have cytotoxic properties, many of which showing an antitumor potential. Alkaloids and terpenes, mainly diterpenoids and sesquiterpenes, are the main types of bioactive molecules in nudibranchs.
The exam notes that many of these compounds are not nudibranches (sea slugs) emerge promising new manufactured by the nudibranchs nudibranches (sea slugs) emerge promising. themselves but are sequestrated with their diet. such as sponges, and sometimes chemically modified for their own defense.
A study has demonstrated powerful cytotoxic effects of extracts from methanol-dichloromethane derived from Dolaabella Auricciarry et Phyllidia varicosa Against. cellular cancer cell lines (CRC). Another study reported a lower cytotoxic effect of acetone extracts derived from Spotted armina. Tricolored armyet Armina Tigrina Against cell lines in lung and stomach cancer.
Acetone extracts from Phyllidia celestial have been purified to obtain bisabolane type of equity such as 7-Isocyan-7. 8-Dihydro-bisabolène, Theonelline isothiocyanate and 3-Isocyanotonellin. In particular. the article emphasizes that the structural analogues of these compounds have also been found in the prey of Nudibranch. In Axin Variabilisstrongly suggesting a food origin for these metabolites.
Studies have reported cytotoxicity of 3-isocyanotheellin against cell lines of lung, liver, CRC and pancreas, and 7-Isocyano-7.8-Dihydro-α-Bisaboléne and theonelline isothiocyanat nudibranches (sea slugs) emerge promising new against a cellular cancer line.
Powerful isoquinolinequinone alkaloids derived nudibranches (sea slugs) emerge promising from Jorunna fuebris have shown an anti -tumor activity against. various cancer cellular lines. Examples include foubricin against leukemia. lung cancer cell lines. M Reorieamcin Ms against CRC cells and lung cancer and melanoma, lymphocyte leukemia and lung cancer cellular lines. These compounds belong to a class of aromatic alkaloids characterized by messengers of merged quinone. isoquinoline, often associated with DNA-interactive and pro-apoptotic activity.
In another example of compounds showing an activity against cancer difficult to process. the document mentions the phorbazole alkaloids of Aldisa Andersonwhich has demonstrated cytotoxicity against several cell lines known to be. resistant to pro-apoptotic stimuli.
In addition, tambjamines are the main metabolites of Tambja brasiliensis et Tambja Stegosauriformis. Tambjamine K has demonstrated an anti -tumor activity in glioma. cellular cancer lines of the cervix. although the review notes that certain tambjamines nudibranches (sea slugs) emerge promising new also have toxicity against non -tumor cells, highlighting the critical challenge of the damage nudibranches (sea slugs) emerge promising to selectivity.
Nudibranches (sea slugs) emerge promising new
Nudibranches (sea slugs) emerge promising
A defense reservoir: the role of egg. masses
The review also points out that the bright. exposed egg masses of certain nudibranchs, such as Hexabranchus bloodServe with concentrated tanks for defensive compounds. Molecules like the Ulapualides. isolated from these egg masses. have shown a powerful anti -tuthical activity and can be easier to isolate in larger quantities in relation to extracting them from adult animals, offering another strategic path nudibranches (sea slugs) emerge promising new for the discovery of drugs.
Nudibranche derivative action mechanisms
Research has unveiled several action mechanisms contributing to the antitumor activity of nudibranche compounds. These include induction of DNA nudibranches (sea slugs) emerge promising damage. oxidative stress and endoplasmic reticulum (ER), generation of reactive oxygen species (ROS), stopping cell cycle and apoptosis. A study reported that the isolated dendroderol Dandrodoris smoked presents an anti -tumor activity by inducing apoptosis in leukemic cells.
In addition. another study has shown that Palmadorine m isolated from Austodoris kerguelenensis Inhibit the activation of kinase 1. 2 regulated by the extracellular signal (ERK1 / 2), Janus Kinase 2 (JAK2), and the transducer of the transcription 5 (Stat5), inducing apoptosis in leukemia cells. Methanol-Dadhloromethane extracts P. Varicosa et AURICAL D. have anti-tumor and anti-proliferative effects by inducing DNA damage, oxidative stress and apoptosis in CRC cell lines.
A later study reported that nudibranches (sea slugs) emerge promising new the AURICAL D. The extract had a selective cytotoxicity against CRC cells. a minimum impact on normal colon fibroblasts. Antitumor activity was mediated by the generation of ROS, inducing stress and activation of the response of unfolding nudibranches (sea slugs) emerge promising proteins. The stress ER mediated by ROS has led to a stopping cell cycle G2 / m, DNA damage and apoptosis.
In addition. similar action mechanisms have been reported for KLM155. a Toluhydroquinone (a hydroquinone derivative) derived from Mindings MilecraIn an esophageal cancer cellular line. Its anti -tumor activity was associated with a cessation of the cell cycle in phase G2. ROS production and induction of apoptosis. nudibranches (sea slugs) emerge promising new In addition to anti -tumor activity, various nudibranch derivatives have other biological activities. For example, A. Tigrine, A. Tricoloratoet A. Mastered The extracts have an anti-inflammatory activity.
Echinoclérodane A, a diterpénoid of Hexabranchus bloodhas powerful inhibitory effects on inflammatory responses in RAW264.7 macrophages. In addition. Foubricin nudibranches (sea slugs) emerge promising acts as an inhibitor of the signaling of the Kappa B nuclear factor (NF-κB). Nudibranchs have also been recognized for antiparasite and antimicrobial potential. For example, compounds with leishmanicide and antibacterial activity have been isolated from Chromodoris I tell you et Starred doriprismaticarespectively.
Nudibranches (sea slugs) emerge promising new
Nudibranches (sea slugs) emerge promising
Final remarks
Together. nudibranchs are a group of marine invertebrates with a largely under-explored pharmacological and biological potential. The study has highlighted the remarkable anti -tumor activity of extracts. compounds derived from the limited number of nudibranchs studied to date.
Despite the nudibranches (sea slugs) emerge promising new promising results, the examination stresses that additional research is necessary to corroborate the clinical potential of nudibranch derivatives. More specifically. the article suggests that future studies should focus not only on the normalization of extraction methodologies. the optimization of isolation and purification protocols, but also on several key areas. These include the exploration of the relatively not nudibranches (sea slugs) emerge promising studied nudibranch group. which have different diets. can produce new compounds; Analyze different anatomical parts of organisms, such as the mantle against viscera; And investigate the microbiome associated with nudibranchs, because their symbiotic bacteria represent another important source of bioactive molecules.
Further reading: Too much screen time in children can increase the risk of heart disease – Researchers successfully test vaccination without needle using dental wire – What if the light could treat Alzheimer’s? – Risk of hepatitis or HIV: recommended screening for nudibranches (sea slugs) emerge promising new 4,400 patients in the dental office at Maubeuge hospital – At 57. he thought he was healthy, but this unique symptom he suffered was in fact a sign of inoperable cancer.
Further reading: A case of aicopper recorded in Tougué – Guineénews © – “I am a gastroenterologist and here is the drink I have every morning for the health of my intestines” – The Quebec Superior Court has decided | New backhand for anti -abortion activists in Quebec – Oropouche: The tropical virus that worries the French authorities-should we fear a new threat this summer? – protect your eyes from the sun, a vital reflex.