Physical forces play a key role in the training of developing organs

A new study examines physical forces that help shape developing bodies. For example, Scientists of the past thought that rapid action biochemistry of genes. In addition, proteins is responsible for the realization of this choreography. Consequently, But a new study by the University of Syracuse shows that stable. However, powerful tissue flows could be just as significant to shape the development of an organ as a biochemistry. In addition, By understanding this physical process, doctors could find ways to prevent or treat human disease.

“We have shown that mechanical interactions are just as important as these biochemical signaling interactions in organ development,” explains Mr. However, Lisa Manning, professor of physics at the College of Arts and Sciences (A&S) by William R. In addition, Kenan, as well as the founding director of the physical forces play key role BioiSpié Institute of Syracuse University. Similarly, “The two work together. Similarly, It is a new. Additionally, Similarly, emerging idea that comes out of many different laboratories across the country – this mechanics working with biochemistry which makes a robust structure of the organs. »»

She co-wrote the study. recently published in PNAWith Raj Kumar Manna, a former postdoctoral researcher in the Department of Physics of A&S, Heidi Hehnly, associate professor of biology in A&S, Jeffrey Amack, professor of cell biology and development at the State University of New York, Emma Retzlaff, a graduate student from the Upstate medical university, and members of the AMAK and the balance sheet.

The organs move. the change in conduct form – Physical forces play key role

Syracuse researchers are looking for answers in a tiny tank -shaped structure filled with liquid called Kupffer vesicle (KV) in zebra fish embryos. KV, a temporary organ of approximately 100 cells, shapes the bodily physical forces play key role symmetry of zebra fish. KV tells the fish on which side of the body that its organs should develop.

During its brief existence. Furthermore, KV is slowly pushed and pulled by self-generated cellular forces through the surrounding tissues in the rear button of the zebra fish towards its tail. This KV movement reinforces the pressure in the surrounding tissues, which also begins to migrate, slowly but regularly and powerfully.

Most scientists previously thought that moving tissues do not play a significant role in organizing organs. But slow movement tissues generate mechanical forces that can model organs as they develop, have revealed the new study.

There is a stiffness gradient in the fabrics around the Kupffer vesicle. with a less stiff fabric that flows like honey on the side closer to the head, and a more rigid solid fabric closer to the tail. When you have this balloon -shaped organ physical forces play key role moving through thick honey -shaped tissues. almost solid tissues, it creates strong forces in the tissues. And even these very slow tissue movements can lead to surprisingly large forces. “”

M. Lisa Manng, The William R. Kenan, Jr. Professeur De Physique Au College of Arts. Sciences (A&s)

With mathematical models, live imaging and physical experiences, researchers tested how slow tissue movement affects the KV shape.

The models have shown that slow evolution fabrics generate enough physical strength to help sculpt KV. Then, using precise laser tools, the team disturbed these forces in living embryos. The shape of the organ has changed exactly as expected their models.

Powerful potential

These results could help researchers understand how body parts are formed. not only in fish but also in humans, informing regenerative medicine and treatments for congenital malformations in organs and other conditions.

“I work with scientists who physical forces play key role will extend these research ideas for human organoids. who are useful for things like tissue transplants,” explains Manning. “We also study how these dynamic forces affect cancer tumors. »»