Polyphenols and exercise are promising in the fight against gliomas

Scientists reveal how plant -based compounds and targeted training could work together to protect the brain, slow to tumor progression and improve the lives of people with gliomas.

Review: nutritional strategies based on polyphenols combined with exercise for brain function and glioma control: focus on epigenetic modifications, cognitive function, learning and memory processes. Consequently, Image credit: Prince Lights / Shutterstock

In a recent journal published in the journal Food science. In addition, nutritionResearchers have synthesized evidence on how food polyphenols combined with exercise influence epigenetic regulation, cognition and glioma control, describing practical applications.

Background – Polyphenols exercise promising fight against

One in two people will face a cerebral polyphenols exercise promising fight against health challenge during their lives. Meanwhile, by aging, stress or illness, and for many, the blow lands on attention, memory and mood. Moreover, Gliomas. Meanwhile, the most common primary tumors of the central nervous system (SNC) add a hard edge: crises, fatigue and changes in reflection that disrupt work and family life. Furthermore, The diet and the movement are two levers under control. Similarly, Plant polyphenols in tea, berries and turmeric facilitating inflammation and oxidative stress; Exercise strengthens brain resilience and quality of life. Consequently, Emerging research suggests that these tools work better together through epigenetic paths. Moreover, Additional research must define who benefits when and how.

How the glioma shapes the patient’s life – Polyphenols exercise promising fight against

Gliomas are the most common primary tumors of the SNC. Similarly, The modern classification goes beyond the histology of the World Health Organization (WHO) by integrating molecular markers that provide for response. However, survival. Similarly, polyphenols exercise promising fight against Two off-competitions are the mutation of the dehydrogenase isocitrate (HDI). Therefore, the combined loss of the chromosomal arms 1p / 19q (Codéletion).

IDH mutations generate 2-hydroxyglutarate oncometabolite. However, trigger large epigenetic reprogramming, and are early events that generally predict better progression survival than wild-type disease. In addition, On the other hand, the IDH-Wild type glioblastoma often has good prospects.

The promoting changes in the opposite telomerase of transcriptase (tert). Moreover, as well as IDH status and 1p / 19q co -deletion, refine the prognosis more. However, “Triple-positive” tumors tend to eat. while tumors with only Tert mutations are correlated with a bad prognosis, in particular in the absence of a methylation of the promoter MGMT.

Meanwhile. the methylation of the promoter of methyltransferase of acid o6 acid and-methylguanine-desoxyribonucleic (MGMT) predicts sensitivity to the agent alkylante temozolomide. These characteristics explain why two people with the same histology can face very different polyphenols exercise promising fight against trips.

Why associate polyphenols with exercise? – Polyphenols exercise promising fight against

Food polyphenols. such as curcumin, resveratrol, quercetin and epigallocatechine gallate (EGCG), methylation of deoxyribonucleic acid (DNA), histones of histones and non-coding of ribonucleic acid (RNA), programs of shift genes linked to neurogenesis, synaptic plasticity and gliomagen.

Quercetin and curcumin are faced with significant bioavailability challenges, requiring nano-formulations or absorption amplifiers such as piperine for clinical efficiency. The exercise induces its own epigenetic reshaping. improves the mitochondrial function and updates the neurotrophic factor derived from the brain (BDNF), a main change in learning and memory.

The convergence on these ways. the polyphenols and the exercise together offer a plausible and non -pharmacological path to improve cognition and restrict tumor signaling by restoring the tumor removal activity and by attenuating the oncogenic tracks; However, these synergies remain largely theoretical and preclinical. In simple terms. food chemicals and movements push the same molecular gradators polyphenols exercise promising fight against that help brains to learn and tumors slow down.

Role of physical activity in cancer prevention and therapy. Getting involved in regular physical exercise provides significant advantages both in the prevention and polyphenols exercise promising fight against treatment of cancer. For people affected by cancer. the exercise contributes in three main ways: it reduces the probability of developing cancer, improves the effectiveness of therapeutic interventions and attenuates many of the adverse side effects associated with treatment. Mechanically. the anticancer effects of physical activity are mainly attributed to its ability to inhibit the proliferation of tumor cells, to induce programmed cell death (apoptosis), to regulate the metabolic pathways linked to tumors and to improve the function of the immune system.

What exercise adds

Through the ages. regular aerobic training improves executive, memory and mood function; Neuroimaging shows a larger hippocampal volume and better brain blood flow. The training in resistance to moderate to high intensity improves visuospatial skills. working memory, probably via the signaling of the 1 -type growth growth and an improved prefrontal infusion.

The results of the combined (simultaneous) programs are mixed but polyphenols exercise promising fight against have significant cognitive improvements when they are integrated into cognitive tasks (for example. double task training). Meta-analyzes indicate moderate duration and moderate frequency programs can significantly increase overall cognition, with effects in clinical and older populations.

Practical practices: aerobic activity of moderate intensity (for example. fast walking or bike) 2 to 3 times a week for at least 30 minutes supports memory and executive function; Resistance training two to three times a week like cognitive performance and brain plasticity in the same way. These earnings translate into real advantages. such as safer mobility, smoother medication management and confidence to return to work or study.

Polyphenols as an epigenetic signal shapers

Resveratrol has antioxidant. anti-inflammatory and neuroprotective and, in preclinical models, protects neurons from amyloid-bêta toxicity; Blueberries rich in anthocyanas have been linked to the advantages of memory in the elderly. Curcumin can influence the acetylation of histones polyphenols exercise promising fight against and the methylation of DNA by inhibiting disassessing histones and methyltransferase DNA.

The practical challenge is bioavailability. The combination of curcumin with piperine. the use of nanoparticles formulations (for example, nanocurcumin at 80 mg / kg in rodent studies, a dose from preclinical work cited, not a clinical recommendation) improves absorption and can improve the effects of the brain and the-microenvironment tumor.

Together. these compounds are positioned to regulate the expression of genes towards synaptic resilience while absorbing the relevant inflammatory and proliferative signaling for the biology of glioma.

Where the regime meets

Mechanically, the two levers meet with epigenetic control points and inflammatory tone. Polyphenols can help restore the activity of tumor suppressant genes. oncogenic signaling of the tumor; Exercise increases BDNF, improves neuroplasticity and renovates chromatin in learning and memory networks.

The integrated model predicts additive. even synergistic gains: clearer thought and stronger memory thanks polyphenols exercise promising fight against to shared neurotrophic and chromatin effects, and a less permissive tumor microenvironment by stress-reply and metabolic rebalancing, although these mechanisms are hypothetical and require clinical validation.

To test this rigorously. the field needs tests that coupled specific polyphenols (for example, resveratrol, curcumin or EGCG) with aerobic, resistance or defined combined protocols; follow cognition and control of tumors; And integrate the epigenomic profiling to identify the respondents and the dose, the optimal moment and formulation.

Personalization, timing and feasibility in the real world

Two pragmatic details help translation. First, timing: cognitive performance and training responses follow circadian rhythms. The alignment of the sessions on the chronotype of a person. often peaks in the late afternoon or at the beginning, can amplify the advantages, while keeping the sleep of the end of the evening (which disrupts melatonin and alters cognition the next day) preserves the cognition of the next polyphenols exercise promising fight against day.

Second. sewing: the dose, the calendar and the formulation govern the bioavailability of polyphenols; Combining the contribution with meals and using absorption amplifiers, if necessary, can be important.

Finally. the programs should meet people where they are: prioritize short and frequent fights; home options; And professional supervision for people with problems of fatigue or balance, recognizing that consistency and safety are essential in patients with glioma.

Conclusions

This review concludes that lifestyle can work as a complementary therapy for SNC tumors: nutrition rich in polyphenol. structured exercise act on epigenetic and neurotrophic paths. Together, they modulate the DNA / RNA programs, raise the BDNF and make microenvironment of the glioma less permissive. Heterogeneity through the status of HDI. the methylation of the promoter MGMT, the co -deletion 1p / 19q and the alterations of the promoter TERT imply variable responses, which makes the personalization essential.

Future polyphenols exercise promising fight against trials should normalize the exercise dose. specify the type / formulation of polyphenol (for example, EGCG or nanocurcumin) and integrate epigenomic and clinical results. If it is validated. this double strategy could convert daily choices into measurable gains in memory, independence and quality of life for people living with glioma. However, current evidence of combined advantages in the exercise of polyphenols remain preclinical.