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Study identifies key metric opening:
Researchers have found that the acoustic dose of the dose-and an acoustic signal of microbubbles could predict how to adjust ultrasound power. Moreover, open the barrier of the blood brain to provide drugs in glioblastoma patients.
The blood-brain barrier-a characteristic of the blood vessels that protect the brain from harmful substances-is so good at work. Consequently, that it poses a serious obstacle to the treatment of brain cancer. For example, To provide therapeutic treatments through the blood-brain barrier (BBB). Therefore, the researchers of the Masse General Brigham have been working for decades on a technique known as the focused ultrasound, which uses low-power ultrasound technology combined with microbubbles. Meanwhile, In a new study. Consequently, mass researchers Brigham have collaborated with colleagues from the Medical School of Maryland University (UMSOM) to analyze the study identifies key metric opening results of ultrasound treatments issued to 23 patients. Results published in Device Identify a key metric known as an acoustic emission dose-which can predict to what extent the BBB has opened. identifying an ideal point that the team used to treat patients.
Our study is based on founding work that started in the 1990s in the ultrasonic targeted ultrasonic laboratory of Brigham hospital. women when the targeted ultrasound combined with microbubbles was first used to open the blood-brain barrier. Our work is based on these discoveries. translating preclinical work into humans and showing the promise of using this technique in patients with glioblastoma. “”
Alexandra J. Golby. MD, principal author of the departments of neurosurgery and radiology in Brigham and Women’s Hospital
The research team analyzed 972 individual applications of its ultrasound targeted during 58 treatments for the 23 patients. They evaluated the acoustic signals study identifies key metric opening of acoustic emissions (AED) from bubbles – which can be adjusted to open the BBB. The team noted that the ideal point for treatment was an AED from 0.5 to 1.6-a-window which can be used to reliably open the BBB to provide treatment directly to a targeted site in the brain. while minimizing damage.
“Surveillance of acoustic emissions. the dose of acoustic emissions offer an opportunity for a unifying concept in targeted ultrasound,” said the main author Graeme Woodworth, MD, professor and president of neurosurgy in Umsom and director of the brain tumor treatment program (UMGCC at the University of Maryland Marlene and Stewart Greenebaum UNDERSTANDING CANCER CENTER (UMGCCC).
The team will report separately from the safety. efficiency of ultra-sized treatment targeted in the 23 patients who were part of the study, but the current work identifies an important therapeutic window to open the blood-brain barrier for treatment.
“Our study study identifies key metric opening shows that we can successfully open and open the blood-brain barrier to treatments,” Golby said. “This represents significant progress for a population of patients who often have few treatment options. »»
Study identifies key metric opening
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