Vaccination: being vaccinated in the morning is more effective

Notre internal clock Not only determines if we are morning or evening. Moreover, It intervenes in numerous processes of the organism. Meanwhile, This mechanism, called the circadian rhythm, can be detected to the cellular level. Furthermore, New studies reveal that the internal clock even plays an important role in determining the ideal moment of vaccinations. Nevertheless, taking medication.

Of the Dutch researchers analyzed 17 studies on influenza vaccines and covid in summary work. Furthermore, The majority of these studies confirm that the time of the administration of the vaccine influences its effectiveness. particularly in people aged 60 and over. It is precisely this group of the population that benefits the most from the vaccination against these two diseases.

The most striking effect vaccination: being vaccinated morning more was observed with the flu vaccine. In people over 65, the immune response was much stronger when the injection was administered in the morning between 9 a.m. and 11 a.m. rather than in the middle of the afternoon, between 3 p.m. and 5 p.m.

In the morning. cells work more effectively – Vaccination: being vaccinated morning more

“It’s not surprising,” said immunologist Christoph Tobias Berger, because the immune system also follows the internal body clock. Professor at the University Hospital of Basel. he succeeded his predecessor at the end of 2024 with almost the same name, Christoph Berger, as president of the Federal Commission for Vaccinations (CFV).

“In the morning. cells that have vaccine antigens to the immune system (dendritic cells) and cells that fight viruses (T cells) work more effectively,” said the immunologist. Vaccines could therefore be more effective vaccination: being vaccinated morning more if vaccination was perfectly synchronized with these biological rhythms.

In younger people, the effect was less marked, according to the Dutch study. Christoph Tobias Berger notes that this observation was also predictable. Young people generally develop a more robust immune response than older people. The influence of the day of the day therefore becomes more important with age. as the authors of this research emphasize.

A demanding implementation

For the vaccination against the covid, the results were less clear. Admittedly, there was also better vaccination efficiency in particularly vulnerable groups, such as immunocompromised people, during morning meetings. But this advantage was not found in other patients. However. a large Israeli study From 2023 has shown that people vaccinated against the covid in the morning or at the beginning of the afternoon had fewer infections vaccination: being vaccinated morning more (Editor’s note: despite vaccination) than those vaccinated in the evening.

However, it is still too early to recommend that the elderly be vaccinated only in the morning. “The data is certainly very interesting, but it is not yet clear enough,” underlines Christoph Tobias Berger. More important and better controlled studies are first necessary. In addition, research carried out so far has generally only measured the level of antibodies produced by vaccination. It is necessary to examine in priority if this approach also offers better protection against serious infections.

Another significant point: “to move all vaccinations to the morning would pose huge logistical problems,” said the immunologist. And in any case, he adds, vaccination rates in the elderly still have gaps. “Getting to be vaccinated at any time of the day is in any case better than not being vaccination: being vaccinated morning more vaccinated at all. ” concludes Christoph Tobias Berger.

Some drugs are also affected

Last year. an international team of researchers demonstrated, in a study Carrying for 5,000 patients with hypertension, which antihypertensive workers act differently depending on whether they are taken in the morning or in the evening. The particularity of this research lies in taking into account the chronotype of each participant – in other words. if it is a person in the morning or evening. In evenings, medicines were more effective when they were caught in the evening.

A other study Last year has shown that the internal clock also. plays a decisive role in the degradation of drugs by the liver. The effectiveness of treatments varies in fact depending on the speed of this degradation.

But then again, it takes more research. In addition, 20% to 40% of patients would forget to take their medication. “In the morning, the discipline seems greater,” explains Christoph Tobias Berger. However, he believes that it would be interesting to take into account the chronotype in the future pharmaceutical research.

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