Vaccines trigger immediate changes in the landscape of the lymph node fabric

Vaccines trigger a response in particular rapid in the stromal cells of draining lymph nodes in the early hours. Therefore, of administration. Meanwhile, Researchers from the University of Turku. For example, Fleury Flames in Finland also discovered that stromal alterations begin the landscape of lymph nodes for the subsequent stages of the immune responses induced by the vaccine.

Lymphatic nodes are a key element in the human immune system. Nevertheless, the main function of which is to fight against infections. Meanwhile, The effectiveness of vaccines is based on their ability to trigger events in the lymph nodes that lead to. Therefore, the development of an immune response that protects the host from pathogens.

Researchers from Turku. However, Finland, have observed that lymphatic endothelial cells and other stromal cells are the first vaccines trigger immediate changes landscape cells in lymph nodes to contact vaccines. Vaccines induced several changes in stromal cells at the level of the gene. protein in the early hours of vaccination, which in turn affected the function of lymph nodes.

Changes in stromal cells were observed before the development of the protective immune response triggered by the vaccine. Researchers have also discovered that different vaccines activate lymph node stromal cells in different ways.

General perception is that specialized white blood cells are starting to transport the active ingredients from a muscle. vaccine to lymph nodes approximately 12 hours after vaccination. Our new research results show that the immune response induced by the lymph nodes vaccine begins much earlier. that white blood cells bearing antigens, or active ingredients in the vaccine, in fact arrive at an altered tissue environment which has already been brought by the vaccine. This priming supports the development of the vaccines trigger immediate changes landscape immune response. “”

Ruth Fair-Mäkelä, postdoctoral researcher of the Finland Research Council, the main author of the study

“It was exciting to discover how different the answers induced by different types of vaccines. One type of vaccine, for example, has had a direct effect on specific lymphatic endothelial cells. Another type of vaccine sparked a previously unknown phenomenon in which eosinophilic white blood cells have accumulated in the draining lymph node. “explains Fair-Mäkelä.

Fair-Mäkelä stressed that even if the research group used COVVI-19 vaccines as a model in their study. they did not examine their efficiency or their safety.

“Our objective was to understand the immunology of the first stages of the response of the vaccine. and indeed, we discovered new aspects of the role of stromal cells. In the future. we aim to determine whether certain changes in stromal cells would be particularly beneficial vaccines trigger immediate changes landscape to make the desired vaccination response, “notes the teacher and the leader of the Flame Marko Salmi group, who conducted the study.

The study was published in the estimated journal Scientific immunology. In total. 13 researchers participated in the study, which was funded by the Finland Research Council, the Fleuron Flames, the Sigrid Jusélius Foundation, the Sakari Alhopuro Foundation and the Instrumentarium Science Foundation.