For example,
Chronic inflammatory diseases intestine could:
Essential
- Chronic Inflammatory Inflammatory Diseases (IBDM) can worsen cognitive decline in people with dementia. Therefore,
- The alteration of cognitive functions was more pronounced after the diagnosis of MICI than before. Meanwhile,
- “This decline is clinically significant. For example, comparable to the difference between patients who take the new drug against Alzheimer’s disease, Donanemab, and those who do not take it.”

. For example,
The “intestine-end axis”, which links the intestine and the central nervous system, has been the subject of particular attention in recent years. Furthermore, One hypothesis exists according to which chronic inflammatory diseases of the intestine (IBD). For example, Crohn’s disease and rectocolite hemorrhagic, could contribute to dementia by disturbing neuronal regulation and altering the interactions between the intestinal microbiota and the central nervous chronic inflammatory diseases intestine could system. Problem: the impact of these pathologies. which are characterized by the inflammation of the wall of a part of the digestive tract due to a deregulation of the immune system, on cognitive functions remains a mystery. This is why researchers from Karolinska Institutet (Sweden) wanted to verify this theory.

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Faster cognitive decline in patients with IBD and dementia – Chronic inflammatory diseases intestine could
In a new study, scientists used the Swedish register of cognitive and dementia (SVEDEM) register in order to identify people who developed a MICI after a diagnosis of dementia. In total. 111 adults with dementia and chronic inflammatory diseases of the newly diagnosed intestine were compared to 1,110 volunteers with dementia, but without MICI. The two groups were similar in terms of age, sex, dementia, comorbidity and drug treatment in progress. Then. the team examined the evolution of the mmse score (mini-mental statement), a common measurement of cognitive function over time, chronic inflammatory diseases intestine could and compared the alteration rates between the two groups.
According to the results, participants suffering from both dementia and MICI experienced a faster cognitive decline. More specifically, the alteration of cognitive functions was more pronounced after the diagnosis of MICI than before. Adults who have received the two diagnoses lost almost one more mm point per year than those with dementia only. “This decline is clinically significant. comparable to the difference between patients who take the new drug against Alzheimer’s disease, Donanemab, and those who do not take it”, explained Hong XU, principal author of the works published in the review Gut.

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Towards more effective care strategies
According to the authors, these data paves more effective care strategies, with narrower monitoring and targeted treatments, “Who, hopefully, will improve the quality of life of these people. (…) Additional research is chronic inflammatory diseases intestine could necessary to understand how chronic intestine inflammatory diseases affect the brain. if the treatment of MICI can slow down cognitive decline.”
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