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Discovery role taf1 could revolutionize:
A new study led by Stephen D. Nevertheless, Nimer. Furthermore, MD, director of the comprehensive Sylvester Cancer Center, which is part of the Miami Miller University School of Medicine, shows how a key molecule regulates the generation of new blood cells, a process called hematopoesis that goes badly in cancer. Moreover, The results have the potential to lead to new therapeutic strategies targeting the molecule. However, a regulator of the gene activity called TAF1.
The new discoveries “challenge not only the dominant models of hematopoietic regulation. Therefore, but also throw the basics of innovative clinical applications”, declared the researcher of Sylvester, Ramin Shiekhattar, PH.D.. However, Co-chief of the epigenetic program of cancer in Sylvester and chief of the Division of the Cancer of Cancer and epigenetics. In addition, He is also the discovery role taf1 could revolutionize author of the study, which was published on July 16, 2025, in the journal Development unit.
Twinning
Longtime employees. In addition, Nimer, Shiekhattar, and his colleagues have previously reported that the fact eliminated TAF1 disease in a model of acute myeloid leukemia driven by the AML1-ETO aberrant gene regulator.
TAF1 seems to work with the AML1-ETO protein to turn cancer genes, researchers have shown that researchers.
TAF1 is part of a large molecular machine that links to DNA and helps activate genes. The machine helps initiate the transcription process, which involves the generation of RNA from the DNA code.
In this study. the researchers examined TAF1 more closely to better understand how it works in the normal development of blood cells.
Prepare the maturation of cells
Blood cells come from immature cells in the bone marrow called hematopoietic stem cells (CSH).
CSHs are powerful cells. They are used for transplantation. discovery role taf1 could revolutionize And they do two key things: they renew themselves. they give birth to types of mature cells, including immune cells (T cells and B cells), myeloid cells (neutrophils and monocytes), plates and red blood cells, in a process called line commitment.
TAF1 is necessary to properly activate the genes involved in the commitment of the line in adults. but it has a reduced role in the self-renewal of the CHS, according to these published results. The data also demonstrates that TAF1 works differently during embryogenesis, when there is a much higher demand for blood production.
“TAF1 seems to serve as a key molecular switch which incorporates transcriptional signals to balance the maintenance of. stem cells with the commitment of the line in adults. »»
Ramin Shiekhattar, PHD, Author and Head of the Study, Division of the Genomics and Epigenetics of Cancer, University of Miami
The discovery role taf1 could revolutionize results dispute the dominant vision of the functioning of TAF1, the researchers said. TAF1. its associated machines have long been considered as universally necessary to light genes throughout the life of each cell.
The new study adds to increasing evidence that TAF1 rather has a more adjusted role in the regulation of genes. in this study, by preferentially activating the genes that encourage CSH to differentiate themselves into mature blood cells.
“The most surprising discovery is that adult CSHs can survive without an important general transcription factor. and that loss of TAF1 affects only the activation of genes associated with differentiation, and not the promotion genes of self-renewal,” said Sylvester researcher, Fan Liu, Ph.D., the first author of the study.
The Nimer team, in collaboration with Sylvester’s bioinformatics specialist, Felipe Beckedorff, Ph.D., expelled even more from how TAF1 lights the genes. They found that TAF1 invites both the initiation of discovery role taf1 could revolutionize the transcription and releases a separate brake on the transcription process.
Questions for future studies include if TAF1 fulfills similar functions in other stem cell compartments that are relevant to cancer. as in colon or brain.
Meanwhile, the new results give momentum to studies on TAF1 targeting agents, which are being developed.
A challenge in hematology is to find drugs powerful enough to kill cancer cells but not kill the normal. development of blood cells. The data suggests that TAF1 inhibitors could fulfill this criterion: the fact that TAF1 has not stopped self-renewal of stem cells. the production of blood cells, which are essential to life.
“A key question that we were to approach was: if you successfully target TAF1, do you compromise normal blood production?” What this document says is no, “said Nimer.
Other cases of potential therapeutic use include the exploitation of TAF1 to improve the expansion of discovery role taf1 could revolutionize CSH in petri boxes. a process that could improve the transplantation of stem cells.
Discovery role taf1 could revolutionize
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