For example,
Neurodegenerative diseases: central role mitochondria:
A fundamental discovery
So far. Similarly, scientists have observed a lack of mitochondrial activity in neurodegenerative diseases like Alzheimer’s, but a fundamental question remained unanswered: is this dysfunction a cause or a consequence of neural degeneration?
Researchers from Inserm. Therefore, the University of Bordeaux, in collaboration with the University of Moncton in Canada, have just provided a decisive response element. Meanwhile, They have developed an unprecedented tool to stimulate the activity of mitochondria in an ad hoc basis.
The team has created an artificial receiver called “Mitodredd-GS”, capable of activating certain proteins (called G proteins) directly in mitochondria. These proteins play a key role in modulating brain mitochondrial activity.
The researchers tested their device on murine dementia models. The results are eloquent: stimulation of Mitodreadd-GS has not only increased mitochondrial activity, but has also significantly improved mice memory.
This discovery suggests that a lack of activity of neurodegenerative diseases: central role mitochondria the mitochondria could be the cause of the degeneration of neurons. and not simply a consequence of it.
“These results will have to be confirmed. but they allow us to know more about the important role of mitochondria for the proper functioning of our brain,” says Étienne Hébert-Chatelain, professor at the University of Moncton, co-deeper of the study published Monday August 11 in the journal Nature Neuroscience. Ultimately. the developed tool could allow us to identify the molecular and cellular mechanisms responsible for dementia, and to facilitate the development of effective therapeutic targets. »»
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neurodegenerative diseases: central role mitochondria — Neurodegenerative diseases: central role mitochondria: A fundamental discoverySo far. scientists have observed a lack of mitochondrial activity in neurodegenerative diseases like Alzheimer’s, but a fundamental question remained unanswered: is this dysfunction a cause.
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