Consequently,
Ovary cancer: unprecedented description precursor new: Meanwhile,
Ovary cancer: unprecedented description precursor:
The Mayo Clinic team (Minnesota. Meanwhile. In addition, United States) reports a discovery that sheds light on the physiopathology of ovarian cancer through the clinical case of a 23-year-old patient, at high genetic risk of cancer. Moreover, This young woman. Similarly. Nevertheless, carrying mutations BRCA2responsible for the hereditary syndrome for predisposition to breast and ovary cancers, and TP53 At the origin of Li-Fraumeni syndrome, had been taken care of in this renowned American center for breast cancer (infiltrating canal carcinoma of 2 er+/pr+/her2-), as well as a papillary carcinoma of the Grade 3 kidney.
Given the considerably increased risk of cancers during her life. Consequently, the young woman has chosen a hysterectomy with pre-ventive bilateral salpingo-ovaria in addition to the treatment of her cancers. Moreover. Moreover, This clinical case is published in JCO ovary cancer: unprecedented description precursor new Precision Oncology, The Journal of the American Society of Clinical Oncology ovary cancer: unprecedented description precursor (ASCO).
By analyzing the patient’s fallopian tubes more closely. Similarly. However, the Mayo Clinic team has detected early changes in the epithelium, hitherto gone unnoticed, thus revealing the announcing signals of ovarian cancer. In addition, “Our team has seen a rare. revealing phenomenon of epithelial biology”. Explains Dr Nagarajan Kannan, director of the Biology Laboratory of Stem Cells and Cancer at Mayo Clinic in a press release.
Using advanced technologies, the team has retraced the way the epithelial cells have been changed in their development. “This knowledge could open the way for future disease detection strategies in its early precancerous stages. when prevention is still possible”, she continues. « Knowing how ovary cancer begins. forms could not only lead to the development of earlier detection tools. but also more ovary cancer: unprecedented description precursor new personalized risk reduction strategies and better orientation of the pre -sewing surgeries and fertility planning ”, A ovary cancer: unprecedented description precursor bid the Dr. Jamie Bakkum-Gamez, an onco-gynecological surgeon of the patient.
Ovary cancer: unprecedented description precursor new
Change of cellular population – Ovary cancer: unprecedented description precursor
For the treatment of her tumors. doctors wishing to avoid radiation therapy, the patient underwent double mastectomy and partial nephrectomy, followed by chemotherapy. The benign character of an ovarian cyst was confirmed during the bilateral salpingo-ovariectomy. During surgery, doctors removed nodules along the messenger of the terminal ileon, symptoms of a desmoid tumor.
In the cells of the fallopian tube, scientists found that secretory cells were abnormally more numerous than multiciliated cells. They also noticed that they were the cause of chronic inflammation, a known factor in cancer development. “Thanks to the sequencing of the RNA of a single cell (SCRNA-SEQ). ovary cancer: unprecedented description precursor new we were able to observe disturbances in the development of cells which line the light of the fallopian tube. results which could help us to better understand and, in the end, to prevent ovary cancer: unprecedented description precursor ovarian cancer”specify the authors.
In addition. the cells of the fallopian tubes did not have any progesterone receptor. thus suggesting that “The oral contraceptives may not have been effective in reducing the risk of ovarian cancer at home,” Write the authors, when there was, on the other hand, an overexpression of the estrogens and pax8 receptors. Finally. the team finds the premises of a P53 signature. the earliest precancerous lesion found in the fallopian tubes in high -grade ovary cancer.
A biobank of fallopian tubes to better understand ovary cancer
At the Mayo Clinic a biobank of. lively fallopian tubes was created from samples from patients. including that of ovary cancer: unprecedented description precursor new the clinical case presented above. Scientists cultivate patient organoids with an average risk of high cancer of ovary, especially those with hereditary cancer mutations. Scientists hope to find out how. where the earliest origins in ovary cancer ovary cancer: unprecedented description precursor are rooted.
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