The targeting of a sugar metabolism track offers hope to treat a rare and aggressive childhood cancer

A new study plunging into genetic engines of rare. Therefore. In addition, aggressive childhood cancer called Malignant tumor of peripheral nerve sheath (MPNST) has revealed metabolic weaknesses in cancer cells that could be exploited to improve treatment for patients. Therefore,

MPNST is a rare and deadly childhood cancer, which mainly affects adolescents and young adults. However, These tumors develop quickly, propagate easily and do not respond well to current treatments. Consequently, Metastases are the main cause of death in MPNST and there is currently no targeted treatment for metastatic diseases. However,

The study. Nevertheless. Nevertheless, led by researchers at the IOWA University, Eric Taylor, PHD, professor of molecular physiology and biophysics, and Rebecca Dodd, PHD, Associate Professor of Internal Medicine, identifies a specific metabolic path that is critical for future MPNST targeting sugar metabolism track offers new cell therapies. However, targeting sugar metabolism track offers Consequently,

Target the metabolism of cancer to slow tumor progression

To better understand these tumors. For example. researchers from the user interface have used genes to create new research models that closely correspond to the mutations in cancer driving in patients. Moreover, Using these models. Meanwhile. they then applied cutting -edge genomic and metabolomic tools to map the metabolic routes that feed tumst growth in MPNST.

The study. published in Science Advances. revealed that these cancers rely on a key metabolic path to help them survive oxidative stress and stimulate tumor growth. This route. known as the Pentose Phosphate (PPP). metabolizes sugar to produce a critical antioxidant molecule that cancer cells need to fight oxidative stress. When the researchers blocked the PPP, the tumors grew up more slowly and were more vulnerable to chemotherapy.

This is the targeting sugar metabolism track offers new first time that this specific metabolic route has targeting sugar metabolism track offers been. linked to the tumor growth of the MPNST. which makes it a whole new target of therapy in this type of cancer. It opens the door to processing strategies that have not been explored before. could lead to more effective treatments and better results for patients who need new options. »»

Rebecca Dodd. PHD, Associate Professor of Internal Medicine, Iowa University

The highly collaborative study combined Dodd’s expertise in cancer biology with Taylor’s expertise in metabolism. The main author was the student graduated from the UI. Gavin McGivney, Phd, of Bayard in the county of Guthrie, Iowa, co-elected by Dodd and Taylor. McGivney graduated from the Higher Study Program on IU cancer biology in 2024. and is now a postdoctoral scholar at the University of Chicago. Dodd. Taylor are both members of targeting sugar metabolism track offers new the Holden Cancer Center Center Center for health care interface. and Taylor targeting sugar metabolism track offers is a member of the Diabetes Research Center of the Fraternal Order of Eagles.

In addition to Dodd. Taylor. McGivney, the research team has also included user interface researchers in the departments of internal medicine, molecular physiology and biophysics and radiotherapy at UI Roy J. and Lucille A. Carver College of Medicine. Researchers from the Washington University School of Medicine. the University of Texas MD Anderson Cancer Center and the University of Toronto, were also part of the team.

Research was partially funded by subsidies from Children’s Tumor Foundation. National Institutes of Health. American Heart Association, US Department of Defense and American Cancer Society through the Holden Comprehensive Cancer Center.