Bats live for a long time without developing cancer, a mystery that intrigues scientists. A recent study reveals unique biological mechanisms in these flying mammals.
Researchers at the University of Rochester have discovered that bats have natural defenses against cancer. Their study, published in Nature Communicationsto measure light The crucial role of embarrassed p53 andenzyme telomerase in the prevention of the disease.
The P53 gene, present in humans and bats, acts as a tumor suppressor. In some bat species, such as the small brown bat, the activity of P53 is particularly high. This characteristic eliminates cancer cells effectively without harming the body. The Enzyme Telomerase also plays a key role in the longevity of bats. Its activity supports the regeneration of fabrics, an advantage to age in good health. Bats thus combine controlled cell proliferation and robust immune defense.
The implications for research against human cancer are promising. Understand how bats balance cell proliferation and tumor suppression could open new therapeutic paths. Drugs targeting P53 and telomerase could benefit from these discoveries.
Scientists also explore how these mechanisms could be applied to other species, including humans. Batters thus offer a unique model to study cancer resistance and healthy aging.
What is the role of telomerase in aging?
Telomerase is an enzyme that helps maintain the length of the telomeres, the ends of the chromosomes which shorten at each cell division. This shortening is associated with aging and cell senescence.
The bats present a high telomerase activity, which allows them to regenerate their fabrics and live long without showing signs of premature aging. This characteristic is rare among mammals and offers precious clues for research on longevity.
Controlled activation of telomerase in humans could potentially slow down aging and reduce the risk of age -related diseases. However, uncontrolled activation can also promote cancer, which makes bats a study model particularly interesting for their ability to balance these processes.
