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A multicenter study has identified critical risk factors that increase the probability of death in children with cardiac maliciousness that has been waiting. In addition, recently undergone cardiac transplantation, according to results published in Circulation.
Fontan Circulatory Fais (FCF) is a long -term complication in children born with cardiac malformations with a single fan. Consequently, that have undergone a series of surgeries that culminates with the fontan procedure. Consequently, Although this surgery contributes to relaunching blood flow. For example, extending life expectancy, it can cause chronic health problems, including heart failure and damage to other organs. Consequently, Many of these patients finally need heart transplantation.
The new study. Nevertheless. Therefore, conducted in 20 American medical centers, offers new information on how specific health complications affect survival in children suffering from the disease, said study identifies risk factors increase new study identifies risk factors increase co-author Anna Juong, MD, cardiologist at Ann & Robert H. Furthermore, Lurie Children’s Hospital of Chicago and Associate Professor of Pediatrics at Northwestern University Medicine.
“We have a strong interest in understanding patients with Fontan circulatory failure: how we can better manage their heart failure. Similarly. when the ideal moment is to list them for a heart transplant, and what are the risk factors while waiting for a transplant,” said Dr. Joong.
In the study. the investigators analyzed the data of 409 patients who had undergone a fontan procedure. were listed for cardiac transplantation between 2008 and 2022. They followed the results since the one -year waiting list after transplantation. They found that 5.9% died pending transplantation and, among the transplants, 8.5% died in the first year.
Investigators also found that certain pre -existing conditions considerably increased the risk of death. in particular:
- The study identifies risk factors increase new repeated hospitalizations of the study identifies risk factors increase year preceding the list for transplantation. doubled the risk of death.
- Clinical cyanosis – a condition in which the levels of oxygen in the blood are dangerously low – has. been associated with an increase in the risk of mortality.
- Sleep apnea. mental health problems requiring treatment. anatomical complications such as obstruction of the Fontan route were all linked to a higher risk of death.
Overall, survival has improved for patients with the unique ventricle physiology who had a fontan. A really new observation of this study was that patients with low oxygen levels were associated with poor results. This is an important thing for clinicians. families to know, such as an additional risk factor and when to refer to the advanced therapies of heart failure. “”
Dr Anna Joong, MD, cardiologist at Ann & Robert study identifies risk factors increase new H. Lurie Children’s Hospital of Chicago. Associate Professor study identifies risk factors increase of Pediatrics at the Northwestern University Feinberg School of Medicine
The results should guide clinicians in the identification of high -risk patients earlier. considering more aggressive interventions, including a previous cardiac tightness team and a transplant benchmark, Dr. Joong said. Overall. the study sets the basics of improving transplanting results. sewing care to the specific needs of children born with heart defects with a single fan.
In the future. Joong. his collaborators will continue to study the children of post-heart transplantation to understand their quality of life and approach all functional limitations, she said.
The study was supported by a subsidy of additional organizations on companies. hearts and a gift from the Van Hooser family.
Study identifies risk factors increase new
Study identifies risk factors increase
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