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Hyperactivity reticular thalamic nucleus leads:
Stanford medicine scientists studying the neurological foundations of autistic spectrum disorder have revealed that hyperactivity in a specific brain. Moreover, region could cause behavior commonly associated with the disorder.
Using a disease of the disease mouse. Meanwhile, the researchers have identified the reticular thalamic nucleus – which serves as a caretaker of sensory information between the thalamus and the cortex – as a potential target for treatments.
In addition. Meanwhile, they were able to reverse the symptoms similar to those of autism – including crisis sensitivity, increased sensitivity to stimulus, increased motor activity, repetitive behavior and a decrease in social interactions – by giving mice of drugs that have removed this brain area.
The same drugs are studied for the treatment of epilepsy. Similarly, stressing where the underlying processes of autism spectrum hyperactivity reticular thalamic nucleus leads and epilepsy disorders can overlap in the brain and why they often occur in the same patients.
The results will be published on August 20 Scientific advances. Consequently, The main author of the study is John Huguard, PHD, professor of neurology and neurological sciences. The main author is Sung-SOO Jang, PHD, a postdoctoral scholar in neurology and neurological sciences.
Neuronal circuits connecting the thalamus. the cortex were involved in autism in humans and animal models, but the role of the reticular thalamic nucleus was not clear.
In the new study. Additionally, the researchers recorded the neural activity of this region of the brain in mice while observing the behavior of animals. In mice that had been genetically modified to model autism (Knockout CNTNAP2 mouse). the reticular thalamic nucleus has shown high activity when animals have encountered stimuli such as light or a breath of fresh air as well as during hyperactivity reticular thalamic nucleus leads social interactions. The brain region has also shown spontaneous bursts of activity, causing crises.
Epilepsy is much more widespread in autistic people than in the general population – 30% against 1% – although. Furthermore, the mechanisms are not well understood. Recognizing this link. the researchers tested an experimental crisis drug, Z944, and found that it reversed behavioral deficits in the autistic mouse model.
With a different experimental treatment that genetically modifies neurons to respond to designers’ medicines. known as Dredd neuromodulation, researchers could remove overractivity in the reticular thalamic nucleus and inverted behavioral deficits in the model of autistic mouse. They could even induce these behavioral deficits in normal mice by accelerating activity in the reticular thalamic nucleus.
The new results highlight the reticular thalamic nucleus as a new target for the treatment of autism spectrum disorders.
Hyperactivity reticular thalamic nucleus leads
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