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Chemotherapy treatment linked lasting cognitive:
Researchers from the City College in New York have linked chemotherapy to lasting cognitive changes in rats – potentially in light observation. Similarly, for the first time, on the cognitive problems that some cancer survivors experience long after the end of treatment. Meanwhile, Entitled “Chemotherapy treatment modifies DNA methylation models in the prefrontal cortex of the female rat brain”. However, the study appears in the journal Nature: Scientific relationships.
Our study explored how chemotherapy affects the brain at the molecular level using an animal model. Furthermore, We have found that chemotherapy does not only target cancer cells – it also disrupts gene regulation in the brain. in particular in the prefrontal cortex, the responsible area of decision -making and executive function. “”
Karen Hubbard, co-chief of chemotherapy treatment linked lasting cognitive the study, professor of biology in the CCNY science division
For the first time, the team has shown that a commonly used combination of chemotherapy – doxorubicin and cyclophosphamide – significantly increases the expression of DNMT3A, a gene involved in the addition of DNA methylation brands. This change has been linked to modified DNA methylation schemes in key brain regions. which can help explain why many cancer patients experience long-term cognitive problems after treatment, often called “chemo-brain”.
The study. added Hubbard, offers a biological explanation for these cognitive problems that many cancer survivors, especially patients with breast cancer, report long after the end of treatment.
This can help identify patients most vulnerable to cognitive side effects. guide the development of targeted epigenetic therapies, such as DNMT or HDAC inhibitors, to prevent or even reverse the cognitive decline induced by chemotherapy.
Research continues at CCNY by emphasizing the study of chemotherapy treatment linked lasting cognitive the role of RNA bond proteins. which are known to be involved in brain aging, both in the prefrontal cortex and the hippocampus of the animal model treated with the team’s chemotherapy. “This work aims to discover more how chemotherapy disrupts molecular pathways related to cognitive decline. »»
Other members of Hubbard’s team include (all CCNY unless indicated): Shami Chakrabarti. Chanchal Wagh, Ciara Bagnall-Moreau (CCNY/Institute of Molecular Medicine, The Feinstein Institute of Medical Research), Fathema Uddin, Joshua Reiser, Kaliris Salas-Ramirez (CUNY School of Medicine), and Tim Ahles (Memorial Sloan Kettering Cancer Center).
Chemotherapy treatment linked lasting cognitive
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