Lamas, unexpected allies
Lamas have a remarkable feature: their antibodies are much smaller than those of humans. Scientists have exploited this characteristic to create “nanocorps”, miniaturized versions of antibodies capable of crossing the blood-brain barrier and thus reaching a key brain receiver involved in schizophrenia.
“The therapeutic effect of these nanocorps was evaluated in two preclinical models of schizophrenia,” said the CNRS in a press release. The administration of the nanocorps made it possible to correct the cognitive disorders observed in these two murine models: the cognitive functions of the animals are clearly improved from the first injection, with a prolonged effect for more than a week. »»
In addition, nanocorps have the advantage of being biodegradable and inducing limited side effects, a crucial point for patients who often have to follow life treatments.
Although these results are promising, the path to a treatment available for patients remains long. Clinical studies in humans will be necessary to confirm the efficiency and safety of this approach.
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Source: Health destination