Similarly,
Male contraceptive pill tested humans:
In terms of contraception. Therefore, male options have long been limited to the condom/vasectomy duo, leaving the contraceptive load mainly on the shoulders of women. Therefore, This could soon change since the innovative male contraceptive pill. For example, without hormones and reversible, could soon be used in our daily lives.
The first pill of this kind. Meanwhile, called YCT-529, has just succeeded in its first test, reports the magazine online Live Science: it was a question of whether or not it caused serious side effects. Therefore, The trial carried out on 16 volunteers has not revealed any, thus opening the way to larger clinical trials. Therefore, One more step towards the marketing of this revolutionary contraceptive solution.
The scientific journal Communications Medicine has just published the details of this key stage. Nevertheless, For the scientific community. it is a major advance: “We cruelly need reversible contraceptive methods for men”confirms Doctor Stephanie Page, endocrinologist at the University of Washington Medicine School.
The great originality of this pill? It acts without hormones. Its effect is based on the blocking of a key protein. the receiver of alpha retinoic acid, essential for the production and maturation of sperm. By interrupting this mechanism, the pill puts the manufacture of sperm in pause, temporarily and therefore reversible.
Mouses and men
During preclinical tests in mice, the drug showed surprising efficiency. In just four weeks, the fertility of the male contraceptive pill tested humans males was suspended, then restored once the treatment has been arrested. Same success in primates, offering encouraging perspectives for humans.
For the very first clinical trial. the choice fell on men who have already undergone vasectomy, a precaution in the event of possible persistent effects. The volunteers tested different dosages of the drug. under different conditions (on an empty stomach or after a generous meal) and the results were reassuring: the absorption rate is good and no serious adverse effects were detected.
At this stage. the researchers are moving towards a final dose close to that tested at 180 mg, probably to be taken daily, even if the next phases will refine this protocol.
The next goal? Test the pill for several weeks. on an extended and diversified panel, especially with those who have already chosen not to design children. If the future trials confirm the promising results obtained so far. the balance male contraceptive pill tested humans of “which does what” in contraception could well change in a sustainable way and offer men the same level of reproductive autonomy as that reached by women since the pill revolution.
The arrival of a male contraceptive pill would sign an immense societal progress. making it possible to better distribute the responsibility of contraception within the couple and to broaden the choices for all.
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Male contraceptive pill tested humans
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