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New study reveals surprising mechanism:
A new international study led by researchers from Moffitt Cancer Center. Nevertheless, the Karolinska Institute and the Cancer Center of the University of Texas MD Anderson discovered a surprising mechanism of resistance to immunotherapy: the capacity of cancer to injure nearby nerves.
The study. For example, published in Natureshows that when cancer cells infiltrate and damage the nerves associated with tumors, it triggers an inflammatory response which ultimately weakens the effectiveness of anti-PD-1 immunotherapy. Therefore, This widely used treatment works by releasing the body’s immune system to attack tumors, but many patients do not respond.
Our results show that the nerve lesion induced by cancer is not only a spectator effect. Similarly, it directly shapes the immune environment so as to allow tumors to escape treatment. In addition, Above all, we new study reveals surprising mechanism have also found that this process is reversible. “”
Kenneth Tsai, MD, PH.D.. Co-Corresonding Author of the study and co-director of Donald Adam Melanoma and cancer of Moffitt skin cancer
By using patient samples, including those recent trials of neoadjuvant therapy and preclinical models of cutaneous epidermoid carcinoma, melanoma, gastric cancer and pancreatic cancer, the team has shown that cancer cells degrade the myelin sheath protecting nearby nerves. Wounded neurons release inflammatory signals. including IL-6 and type 1 interferons, which can be repaired initially, but over time, creates chronic suppressive tumor microenvironnement.
The researchers tested several strategies to disturb this cycle. Resistance to anti-PD-1 therapy has been overcome by eliminating the nerves that transmit pain. blocking key signals from neural lesions or combining anti-PD-1 with drugs that target the way IL-6.
“This work highlights a new role for the nervous system in the progression of cancer. new study reveals surprising mechanism resistance to therapy,” said Tsai. “By targeting the signaling that follows nerve lesions. we can be able to restore the ability of the immune system to fight cancer. »»
Discovery could lead to new treatment combinations that improve results for patients whose tumors invade. develop along the nerves, a common characteristic in several types of cancer associated with a bad prognosis.
“This is an example of how the study of the counterpart between cancer. nerves and the immune system can reveal entirely new vulnerabilities,” said Tsai.
The study was supported by the National Institutes of Health (CA016672, P30CA016672 and P30-CA076292).
New study reveals surprising mechanism
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