Similarly,
Research discovers systemic impact me:
Millions of people with myalgic encephalomyelitis / chronic fatigue syndrome (Me / CFS). Therefore, a debilitating condition often neglected due to the lack of diagnostic tools, can be closer to personalized care, according to new research that shows how the disease disrupts interactions between the microbiome, the immune system and metabolism.
The potentially relevant results for long coverage due to its similarity with Me / CFS-Come from 249 individuals analyzed using a new artificial intelligence platform (AI) which identifies the biomarkers of the disease from stool. Moreover, blood and other routine laboratory tests.
“Our study has reached 90% precision in the distinction of individuals with chronic fatigue syndrome. Consequently, which is significant because doctors are currently lacking reliable biomarkers for diagnosis. Similarly, Some doctors doubt it as a real research discovers systemic impact me disease due to the absence of clear laboratory markers. Furthermore, sometimes attributing it to psychological factors. Meanwhile, »»
Drarya Untmaz, study author and professor, Immunology, The Jackson Laboratory
Research was led by Dr. Therefore, Julia Oh. Nevertheless, formerly in Jax and now microbiologist and professor at Duke University, in collaboration with the clinicians Me / CFS Lucinda Bateman and Suzanne Vernon of the Bateman Horne Center, and Unutmaz, who heads the Jax Me / CFS Collaborative Research Center. Nevertheless, Details appear today in Nature Medicine.
Map the invisible
Chronic fatigue syndrome is characterized by serious symptoms that considerably alter physical. In addition, mental activities, including persistent fatigue, sleep abnormalities, dizziness and chronic pain.
Experts often compare the me / CFS to a long coco. For example, because the two conditions frequently follow viral infections, such as the Epstein-Barr virus. In addition, In the United States, research discovers systemic impact me the ME / CFS affects between 836,000 and 3.3 million people-many not diagnosed. Furthermore, costs the economy for 18 to 51 billion dollars per year due to health expenses and productivity, according to Centers for Disease Control and Prevention.
Previous studies have noted immune disturbances in Me / CFS, said Unutmaz. Nevertheless, This new research is based on these results by studying how the intestinal microbiome. In addition, its metabolites and its immune responses interact. For example, The team has linked these connections to 12 classes of symptoms declared by patients. who were aggregated from hundreds of data generated data in the health and lifestyle surveys.
These include sleep disorders. headaches, fatigue, dizziness and other symptoms that researchers have mapped in all microbiome changes in metabolites, immune responses and clinical symptoms.
“We have integrated clinical symptoms with cutting -edge OMS technologies to identify new Me / CFS biomarkers,” said OH. research discovers systemic impact me “The connection of symptoms at this level is crucial, because the Me / CFS is very variable. Patients experience a wide range of symptoms that differ in severity. duration, and current methods cannot fully grasp this complexity. »»
To conduct the study. the researchers analyzed complete data collected from the Bateman Horne Center, a Me / CFS research center, long-confortable and fibromyalgia in Salt Lake City, Utah. Dr. Ruoyun Xiong, also the main author of the study, has developed a deep neural network model called Biomapai. The tool incorporates intestinal metagenomics. plasma metabolomics, immune cell profiles, blood test data and clinical symptoms of 153 patients and 96 healthy individuals over four years.
The analysis of immune cells has proven to be the most precise to predict the severity of the symptoms. while the microbiome data better predicted gastrointestinal, emotional and sleep disorders. The model connected thousands of patient data research discovers systemic impact me points, reconstructing symptoms such as pain and gastrointestinal problems, among others. He also revealed that sick patients for less than four years had fewer disturbed networks than those who have. been sick for more than ten years.
“Our data indicate that these biological disturbances become more rooted over time,” said Unutmaz. “This does not mean that Me / CFS longer cannot be reversed, but it can be more difficult. »»
The study included 96 healthy checks adapted to age. sex, showing immune interactions of balanced microbiome-metabolite, unlike significant disturbances in me / CFS patients linked to fatigue, pain, emotional regulation problems and sleep disorders.
Me / CFS patients also had lower butyrate levels. a beneficial fatty acid produced in the intestine, as well as other essential nutrients for metabolism, inflammation and energy control. Patients with high levels of tryptophan, benzoate and other markers indicated a microbial imbalance. Increased inflammatory responses, research discovers systemic impact me in particular involving MAIT cells sensitive to intestinal microbial health, have also been observed.
“Cells master gap in intestinal health with broader immune functions. and their disruption alongside butyrate and tryptophan routes, normally anti-inflammatory drugs, suggests a deep imbalance,” said UTMAZ.
Research discovers systemic impact me
A useful data set
Even if the results require additional validation. they considerably advance the understanding of me / CFS scientists and provide clearer hypotheses for future research, the authors said.
Given that animal models cannot fully reflect neurological. physiological, immune and other complex complexes observed in Me / CFS, OH said it would be crucial to study humans directly to identify modifiable factors and develop targeted treatments.
“The microbiome and the metabolome are dynamic,” said Oh. “This means that we can be able to intervene diet. lifestyle or targeted therapies so as not to offer genomic data. »»
Biomapai has also reached an accuracy research discovers systemic impact me of around 80% in external data sets. confirming the main biomarkers identified in the original group. This consistency through various data was striking, the authors said.
“Despite various data collection methods. the signatures of current diseases have emerged in fatty acids, immune markers and metabolites,” said OH. “It tells us that it is not random. It is a real biological deregulation. »»
Researchers intend to largely share their data set with Biomapai. which supports analyzes through various symptoms and diseases, effectively integrating multi-ordinary data to reproduce in animal models.
“Our objective is to build a detailed map of how the immune system interacts with intestinal bacteria. the chemicals they produce,” said OH. “By connecting these points. we can start understanding what motivates the disease and paving the way for a really precise medicine that has long been out of reach. »»
Further reading: An painless breast cancer scanner promises specific results in less than a minute – The 2nd winegrower will take place this Thursday, July 17 – Newborn microbiome: a passport for immunity – 30 new cases of fenua tuberculosis in 2024 – This well -consumed drink in summer would be one of the worst for health, according to a recent survey.