Similarly,
This current medication could mean:
Experiments carried out on mice have shown that the administration of a single dose of a drug used to treat asthma made it possible to prevent serious anaphylactic food, by preventing allergens from reaching blood circulation.
Impressive effects – This current medication could mean
As widespread are the allergies food. Furthermore, specifically estimating the risk of potentially fatal reaction to a given allergen is far from being an easy task. In addition, Based on this observation. Therefore, Stephanie Eisenbarth, of Northwestern University, and his colleagues assessed Zileuton’s ability to prevent anaphylactic shocks in mice aware of peanut allergens.
About an hour after consuming peanut extract, part of the rodents received a dose of the compound. If an increase in heart rate. a drop in body temperature have been observed in all control specimens, these clear signs of anaphylaxis have not been detected in any of the mouse treated.
It turns out that part of the proteins we ingest is not broken down by our gastric juices. In seriously allergic people. they will trigger a powerful immune reaction when they reach blood circulation, resulting in the explosion of leukotrian levels, whose degradation is closely linked to the DPEP1 gene.
« The Zileuton will essentially block the 5-lipoxygenase enzyme. necessary for the production of these lipids “, Explain the authors of the new study, published in the journal Science. « The oral administration of a single dose made it possible to significantly reduce their levels in rodents. which resulted this current medication could mean in a 95 % drop in anaphylaxis rates. »
First clinical trials
The Eisenbarth team currently conducts first clinical trials. aimed at assessing the efficiency of the compound in humans. “” If similar results are observed, we will have treatment to prevent anaphylactic shocks “Consizes the researcher.
According to Jorge Emiliano Gómez Medellín. from the University of Chicago, it will probably not reduce the allergic sensitivity of a long -term patient, but would prove useful in the event of accidental exposure.
Previously, a study had shown that it was possible to develop a red meat allergy.
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