What is a brain with Alzheimer’s disease like?

Like a distant nebula housing a black hole. Therefore. Therefore, this cut of entorhinal cortex and hippocampus – two brain regions involved in memory – reveals a gaping hole caused by the death of neurons in Alzheimer’s disease. Furthermore, The cause? Therefore, A massive inflammation caused by the immune cells of the brain. Consequently. the microglies, visible here in yellow, and the presence of aggregates of a protein – Tau – which has become unstable and deleterious, here in the form of blue dots. Two signatures characteristic of Alzheimer’s disease.

This photo was obtained by Danielle Beckman and her team from the National Research Center in Primatology, in California. They introduced in macaques a mutation targeting the tau protein. triggering its destabilization what brain alzheimer’s disease like? new by a process called “phosphorylation”, which reproduces typical alterations of the disease. The objective? To better reproduce the characteristic signs of human what brain alzheimer’s disease like? Alzheimer in primate brains. in order to reveal the mechanisms and test new treatments.