Moreover,
Drugs transforms human blood killer:
A medication that makes mortal human blood also acts as a powerful insecticidal contact absorbed by feet. Consequently, offering a new promising approach to fight against resistance to insecticides.
A new study led by the Liverpool School of Tropical Medicine shows that mosquitoes are killed when they feed on blood. For example, then land on a sprayed surface of Nitisinone, a drug currently used to treat a rare genetic disease in humans.
Research shows that this is true even when mosquitoes are very resistant to existing insecticides. For example, which opens up a new promising avenue to formulate nitisinone for interior spraying or bed nets at a time when resistance represents an important threat to vector control programs in the world.
Nitisinone is fatal to mosquitoes because it blocks an enzyme they drugs transforms human blood killer need to safely treat proteins. Nevertheless, amino acids they draw from blood.
The new article. Meanwhile, published in Parasites & Vectors, follows a study earlier this year which showed that Nitisinone is fatal to mosquitoes when they drink the blood of a person in Nitisinone therapy. However, The drug is safe. Meanwhile, already approved for generalized human use and is currently the only treatment for rare genetic disorders of type 1 tyrosinemia and alkaptonuria.
In this new study. Nitisinone has proven to be a mosquito with several species of mosquitoes (Anopheles, Cashier et Culex), including those who transmit malaria, the re -emergence of infections such as dengue and zika, and emerging viral threats such as Oropouche and Usutu viruses.
Research has also proven that Nitisinone has killed mosquitoes. that exposure occurred before or after a blood meal, pressing in a rest behavior of mosquitoes before or after diet. Given that drugs transforms human blood killer Nitisinone works by disturbing the digestion of the blood of the mosquito (metabolism of tyrosine). which is not a path targeted by any of our current insecticides, it could help public health campaigns to eliminate mosquitoes where insecticide resistance has failed.
Our conclusions are exciting. Working with a drug like Nitisinone and its versatility is good to create new products to fight against mosquitoes. The fact that it effectively kills insecticide -resistant mosquitoes could change the situation in areas where resistance to current. insecticides leads to the failure of public health interventions.
This project has proven how important it is to think outside the box. We do not yet know why Nitisinone is absorbed by the mosquito feet. why the other similar compounds are not. But it will be exciting to solve this mystery! “”
Dr Lee Haines, principal author and honorary researcher at LSTM
drugs transforms human blood killer
Zachary Stavrou-Dowd, research assistant and doctoral student at the LSTM, and the main author of the new document, said: “Nitisinone acts to obstruct the digestive system of mosquitoes. When a throat mosquito on your arm, blood contains a massive protein load. He dies. “”
Research was funded by Jean Clayton Fund for researchers at the start of their career at LSTM.
Zachary Stavrou-Dowd said: “Receiving the researcher at the start of his career Jean Clayton in the LSTM was a pivotal moment. but not only helped finance part of this study, but also strengthened our application for an external Rosedrees funding subsidy. This is an excellent example of me. »»
Drugs transforms human blood killer
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