These passages are not simple impressions; Thousands of molecules and health indicators then change suddenly, influencing the skin, muscles, immune system or the liver.
This research, carried out on many Californian participants living between 25 and 75 years old, invites us to observe our health as an adventure punctuated with key stages rather than a progressive decline. Behind these revelations, a clear incentive: to adopt prevention reflexes to best cross these decisive moments of the forties and the sixties.
Understand the two key ages where the body aged suddenly
Many who have always declared that they have felt a sudden change in the forties or when entering the sixties. However, science has just confirmed these testimonies in a large -scale study conducted by Stanford Medicine. Under the direction of Michael Snyder, nearly a thousand participants, men and women in good health, were followed in California over several years.
Every three to six months, their biological data, including the analysis of more than 18,000 molecules such as proteinlipids, and metabolites have been collected and crossed with other parameters such as microbiome or metabolism.
The results are final: between 44 and 60 years, two major peaks of aging appear, overwhelming processes that we had so far believed slow and progressive.
According to sources such as Passion Health or Beauty Test, it is even a “revolution” in understanding aging. Remarkable fact: these changes are observed in everyone, regardless of sex. Long attributed to menopause, the first alterations also affect men, which questions many stereotypes and invites you to rethink prevention.
Accelerated aging at 44 and 60 years old: what health research reveals
According to the Xiaota Shen team at the University of Stanford, the human body experiences a real “change of era” at two key moments. At 44, metabolism sees its ability to manage thealcoholthe caffeine And the fats decline, causing fatigue and general slowdown. At 60, the table is complicated with a weakening of the kidneys, an increase in vulnerability to maladies chronicles, and a lesser efficiency of immune system. A domino effect is put in place, each organ seeming in turn involved in this phenomenon of “ stroke Mentioned in the press, as the Union recalls.
- 44 ans : First visible biological signs, especially on the skin and muscles
- 60 ans : Amplification of the phenomenon, accent on kidneys and immune defenses
- Changes noted in men and women: getting away from the unique hormonal explanation
Stanford’s search is based on a logic ofâgeotypesor very personal aging trajectories, which could soon allow prevention to be adapted to each profile.
Non -linear aging: a revolutionary discovery on biological upheavals
Until now, it was admitted that time damaged each system of corps at a constant speed. The North American survey demonstrates the opposite: the aging is marked by changes Suddenly, real “shocks” at the heart of our biology.
In question, a conjunction of factors:
- Transformation of the digestive microbiome influencing the ability to assimilate certain nutrients
- Rapid modifications of molecular signature in the blood, impacting general reactivity
- Disruption of communication between organs, often aggravated by the stress of the quarantine or the transition to sixties
This milestone operation could shed light on the feeling of many individuals, sometimes destabilized in the face of the emergence of changes sudden physical. Concrete examples illustrate this observation: Luke, a former dynamic executive, saw his energy brutally decrease to 44 years, while Claire, a teacher, had to review her stress management at 60, undergoing more frequent infections and slower muscle recovery.
Such a observation promotes collective awareness: to better understand these moments of transition is also better to prepare for it.
What are the metabolic changes at 44 and 60 years old? Analysis according to AGING
The study published in Nature Aging sheds light on changes Precise metabolic which occur at these two phases of life, based on a large sample of volunteers followed in Stanford, California.
At 44: metabolism, skin, muscles and cardiovascular health impacted
Around the quarantinemany markers of aging jump. Researchers note that the ability to eliminate thealcohol or the caffeine Decreases, making these substances more difficult to tolerate.
This real turning point is accompanied by concrete observations:
- Slowdown in metabolism hepatic and lipidic
- Skin thinning, appearance of wrinkles, loss of elasticity
- Decrease in muscle mass, increased fatigue
- New sensitivity to variations in cholesterol and increase in the first risks cardiovascular
This phenomenon does not only concern an organ but a whole network of molecules And fabrics, causing what the press calls the “real biological jump” linked to mid-life. In terms of experience, some report slower recovery after sport or increased vulnerability to the sun, justifying the need for the sunscreen Even outside the holidays.
At 60: immune wealth, kidneys and increased vulnerability to chronic diseases
The transition to the sixties turns out to be even more marked, this time touching the deep mechanisms of the corps entire.
- Notable drop in the efficiency of immune system
- Gradual decrease in kidney filtration (ability to eliminate toxins)
- Reduction in carbohydrate tolerance, increase in diabetes and other maladies chronic
- Increased frequency of infections and lower recovery after physical effort or operation
The authors recall that, although these changes Obviously can be observed, the speed of their appearance highlights the importance of lifestyle. For many, it is also time to retire, with a modification of thephysical activity daily and sometimes a loss of bearings.
How to mitigate the impact of “old -fashioned” according to science?
If there is no magic recipe, several simple gestures can make a real difference, especially around 44 and 60 years old.
- Practice daily walking: no need to aim for 10,000 steps, 4,000 are enough to significantly reduce mortality
- Opt for a type diet Cretan regime (rich in fruits, vegetables, olive oil and fish)
- Protect the skin every day using sunscreeneven outside the summer
- Maintain regular sleep hours and reduce the consumption ofalcohol
- Favor a physical activity adapted throughout the year
- Learn to manage your stress, through yoga, meditation or participation in collective workshops
Hope now lies in the adaptation of public health policies and the development of follow -up tools adapted to each course, based on discoveries such as those of the team of Michael Snyder and Xiaotao Shen. For those who wish to age in health, these data represent less fatality than a roadmap to act on a daily basis and rethink its future with optimism.
