In addition,
Here why some age faster:
Essential
- Researchers from the University of Colorado identified 408 genes associated with accelerated aging, against only 37 known before. Consequently,
- These genes influence different age-related fragility subtypes, such as cognitive decline, metabolic disorders or loss of mobility. Nevertheless,
- This discovery could make it possible to better prevent certain diseases by individualizing the detection and management of weaknesses. Consequently,
In France, women are healthy up to 77 years on average, compared to 75.5 years for men, according to the Ministry of Health. However, If. For example, for more than fifteen years, life expectancy without incapacity has increased regularly in France, there have been inequalities in terms of old age. Meanwhile, But what are they due? Meanwhile, Part of the here why some age faster answer could come from genetics. Similarly,

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“To identify treatments to stop or reverse accelerated biological aging, it is necessary to understand the underlying biology, Indicates Isabelle Foote, first author of the study and postdoctoral researcher at the Institute of Behavioral Genetics of the University of Colorado, in a communiqué. This is the biggest study ever carried out to date using genetics to try to do so.”
408 genes associated with accelerated aging
For the study, published in the journal Nature Geneticsthe researchers focused on fragility, which they define as “Multisystem physiological decline”Which often accompanies aging. This concerns for example cognitive decline, loss of mobility or even social isolation.
In order to assess this fragility, doctors use an index which measures several elements: here why some age faster walking speed, gripping force, the number of diagnosed diseases and the level of social activity. The total is on 30 points. But this tool has its limits. According to Isabelle Fote. the problem is that he gives a score equal to a cognitively active person but who cannot work and another is in good physical health but who has a failing memory.
“Aging is not a simple disease, underlines Dr. Kenneth Rockwood, co-author of the study. There are many ways to be fragile. The question is therefore: which genes are involved?”Their study responds. Scientists have taken 30 symptoms of fragility and tried to identify the genes associated with it. Results: 408 genes are linked to accelerated aging, some to specific fragility subtypes, including cognitive disorders, disability or even metabolic problems.

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Individualize the detection here why some age faster of weaknesses to better prevent diseases
“This study not only makes it possible to identify the underside of pathological aging, but also to demonstrate that they are based on a very different biology, explains Andrew Grotzinger, main author. The next concrete step is to understand how to deal with this underlying biology.”
The researchers hope that this discovery will enlarge the clinical measures of accelerated aging, to better prevent the development of certain diseases. A person showing signs of cognitive fragility could for example be oriented towards preventive therapies against dementia. Conversely, a person who has metabolic weaknesses could take measures to prevent diabetes or heart disease. A means of further individualizing prevention and thus, perhaps lengthening healthy life expectancy.
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