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Ibuprofen paracetamol common pain relievers:
Ibuprofen and paracetamol are over -the -counter current drugs that many of us reach when we are sick. However, But new research from the University of Australia-Meridional show that these trusted staples quietly feed one of the largest. Nevertheless, health threats in the world: antibiotic resistance.
In the first study of the genre. Therefore, researchers discovered that ibuprofen and paracetamol not only lead to antibiotic resistance when used individually but amplifying it when used together.
Evaluate the interaction of non -antibiotic drugs, ciprofloxacin antibiotic with broad spectrum, and They exhibited chill (E. However, coli) – A current bacteria which causes intestinal infections. For example, urinary tract – the researchers found that ibuprofen and paracetamol considerably increased bacterial mutations, which makes E. Therefore, coli very resistant to antibiotic.
This is an important observation ibuprofen paracetamol common pain relievers which has serious implications for health. especially for people in the healthcare homes for the elderly, where several drugs are regularly administered.
The World Health Organization reports that antimicrobial resistance is a global threat to public health. that bacterial resistance was directly responsible for 1.27 million global deaths in 2019.
The Associate Professor of Senior UNISA Researcher. Rietie Veter, said that the results raise important questions about the risks of polypharmacy in the care for the elderly.
“Antibiotics have long been essential in the treatment of infectious diseases. but their overcrowding and their generalized abusive use have led to a global increase in antibiotic bacteria,” said Professor Assoc Venter.
“This is particularly widespread in healthcare establishments for elderly residential people. where the elderly are more likely to be prescribed multiple drugs – not only antibiotics, but also pain medications, sleep or blood pressure – which makes it an ideal reproduction ibuprofen paracetamol common pain relievers ground for intestinal bacteria to become antibiotic.
“In this study. we have examined the effect of non -antibiotic drugs and ciprofloxacin, an antibiotic that is used to treat skin, intestinal or urinary tract infections.
“When bacteria were exposed to ciprofloxacin alongside ibuprofen. paracetamol, they developed more genetic mutations than with antibiotic alone, helping them develop more quickly and to become very resistant. In a disturbing way, the bacteria was not only resistant to the other antibiotics of ciprofloxacin.
“We have also discovered genetic mechanisms behind this resistance. ibuprofen and paracetamol both activating bacteria to expel antibiotics and make them less effective. »»
The study evaluated nine drugs commonly used in residential elderly care: ibuprofen (anti-inflammatory pain relief). diclofenac (an anti-inflammatory to treat arthritis), acetaminophen (paracetamol for pain and fever), furosemide (for blood pressure) Raised of sugar linked to diabetes), with high blood pressure), a drop in high levels cholesterol and ibuprofen paracetamol common pain relievers fat in the blood), tramadol (a stronger pain medication after surgery), temazepam (used to treat sleep problems) and pseudoephedrine (decongestant).
Professor Assoc Ventier says that the study shows how antibiotic resistance is a more complex challenge than that included. current non -antibiotic drugs also play a role.
Antibiotic resistance no longer concerns antibiotics.
This study clearly reminds us that we must carefully consider the risks of using several drugs – especially in. the care for the elderly where residents are often prescribed a mixture of long -term treatments.
This does not mean that we should stop using these drugs. but we must be more attentive to how they interact with antibiotics-and this includes a look beyond the combinations with two drugs. “”
Rietie is waiting, Associate Professor of Unisa
Researchers are calling for other studies on drug ibuprofen paracetamol common pain relievers interactions between anyone on long -term medication treatment diets so that we can gain greater awareness of the impact of current drugs on the effectiveness of antibiotics.
Ibuprofen paracetamol common pain relievers
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