Immunode-depressed people are sensitive to skin cancer caused directly by beta-hpv

Researchers from the National Institutes of Health (NIH) have shown for the first time that a type of human. Consequently, papillomavirus (HPV) that is commonly found on the skin can directly cause a form of skin cancer called carcinoma of skin squameuses (CSCC) when certain immune cells dysfunction. In addition, The CSCC is one of the most common cancers in the United States and in the world. Meanwhile, Previously. Moreover, scientists thought that HPV had simply facilitated the accumulation of DNA mutations caused by ultraviolet (UV) radiation, generally the main engine of the CSCC. Consequently, The results were published today in The New England Journal of Medicine.

This discovery could completely change the way we think of development. In addition, and therefore the treatment of CSCC in people who have immunode-depressed people sensitive skin cancer a health that compromises the immune function. In addition, This suggests that there may be more people with aggressive CSCC forms that have an underlying immune defect. Similarly, could benefit from treatments targeting the immune system. However, “”

Andrea Lisco, MD, Ph.D.. However, National Institute of Allergy and Infectious Diseases (NIAID)

There are many types of HPV, each tends to infect cells in a particular tissue and part of the body. The types of HPV found mainly on the Bêta-HPV-Sont skin considered as mild members of the cutaneous microbiome which. generally do not integrate into the DNA of skin cells. This contrasts with the alpha types of HPV. known to integrate into the DNA of mucous cells and directly cause cancer of the genitals, anus, head and neck.

NIH researchers discovered in a 34 -year -old woman who came to the NIH clinical center for the immunode-depressed people sensitive skin cancer evaluation. treatment of the recurring CSCC on her forehead. She had undergone several surgeries. part of immunotherapy to try to remove or kill the tumor, but she went up several times. His local doctors thought it was due to a hereditary incapacity to repair damaged DNA by UV radiation. an alteration of immune cells called T cells. The tumor was one of the many diseases related to the progressive HPV that women undergo.

Thanks to a sophisticated genetic analysis. NIH researchers discovered that a beta-hpv had integrated into cellular DNA of the well-established tumor of women and largely produced viral proteins there. This contradicts the dominant theory according to which the beta-hpv facilitates only the establishment of the CSCC without integrating into cellular DNA. does not play any role in maintaining cancer. An additional genetic analysis of women’s cells showed that they were entirely capable of repairing DNA damage by immunode-depressed people sensitive skin cancer UV radiation. suggesting that the virus alone had caused the CSCC.

To understand how beta-HPV could take the unusual steps in integration into the DNA of women’s skin cells. to multiply there, the investigators studied the immune disorder inherited from women. They found that its genetic mutations greatly prevented activation cells in response to the infection by skin cells by beta-HPV. This suggests that the immune disorder itself was responsible for worsening HPV diseases. including the CSCC Beta-HPV on its forehead, and that the treatment of this disorder could cure them all.

Consequently. NIH investigators have developed a personalized plan to give the woman a stem cell transplant to replace her defective T cells with healthy cells. The process required extreme care because it was immunocompromised even before the start of treatment. The transplant took place without complications. Subsequently. all its diseases linked to HPV, including the recurrent and immunode-depressed people sensitive skin cancer aggressive CSCC, have resolved and have not reproduced during the more than three years since transplantation. This confirms that the disorder inherited from the woman had prevented her T cells from keeping the beta-HPV under control. allowing the virus to cause directly and to maintain the CSCC.

“This discovery. the successful results would not have been possible without the combined expertise of virologists, immunologists, oncologists and transplant specialists, all working under the same roof of the NIH clinical center,” said Dr. Lisco.

According to the study authors. their observation suggests that other people with defective T cell responses can also be sensitive to cancer caused directly by beta-HPV.