“Nanocorps” obtained from Lama antibodies could revolutionize the fight against schizophrenia!

French researchers have recently designed “nanocorps” from Lama antibodies. Moreover, The objective? Moreover, Target a type of brain receptor playing a key role in schizophrenia. In addition, According to scientists, these nanocorps have already made it possible to correct the cognitive disorders observed in two mouse specimens. Nevertheless, The hope of seeing a new generation of treatments against schizophrenia arrive is therefore allowed.

Of New perspectives for the management of schizophrenia – "nanocorps" obtained lama antibodies could

Touching approximately 1% of the world’s populationschizophrenia is a psychiatric disease characterized by a set of very variable symptoms. Similarly, the most impressive of which are delusions and other hallucinations. However, affected people are mainly impacted by social withdrawal and cognitive difficulties. Currently, the treatment of this disease is mainly based on antipsychotics, as well as psychotherapy and rehabilitation sessions. In the most extreme cases, doctors use Clozapine, a “nanocorps” obtained lama antibodies could powerful antipsychotic. However. these treatments have only very few effects on cognitive disorders making the lives of patients infernal on a daily basis.

What if it was possible to considerably improve the fight against schizophrenia? Scientists from the CNRS. Inserm and the University of Montpellier have precisely carried out work exploring this issue, the results of which were the subject of a publication in the journal Nature on July 23, 2025. Specialists say they have obtained “nanocorps” (mini-antibodies) from Lama antibodies. For researchers, this work could open the way to a New therapeutic track against schizophrenia.

“Our study opens up new perspectives for the clinical management of brain diseases thanks to. nanocorps immunotherapy using low -frequency peripheral administration. »»can we read in the study.

An improvement from the first injection

Originally from South America. lamas have a particular type of antibodies, which scientists have used to produce nanocorps. However. they can more easily cross the Biological barrier protecting brain cells -the blood-brain barrier-and therefore, would be more effective than current antibodies. The key is in their ability to specifically activate a glutamate receiver playing a crucial role in the regulation. of the activity of neurons.

Biodegradable. limiting side effects and which can be administered by venous or muscular route (peripheral injection), these nanocorps have already made it possible to correct the cognitive disorders observed in two murine models (mouse). According to the authors of the study. the “nanocorps” obtained lama antibodies could cognitive functions of the guinea pigs improved from the first injection And this, with an extended effect for more than a week.

Finally, these works confirm the potential of nanocorps as a new therapeutic strategy to act on the brain. On the other hand, the path is still long. Effectively. Other clinical studies will be necessary To determine whether the ability of nanocorps to correct cognitive disorders actually embodies a new process of treatment for schizophrenia. In the event of positive results. it is possible that in the more or less close future, beyond schizophrenia, other neurological diseases are affected by such treatment.