In addition,
Synjardy now refundable children:
More and more type 2 diabetes in obese adolescents.kwanchaichaiudom / iStock / Getty Images Plus / via Getty Images
Lare two specialties of the range Synjardy film -coated tablet (empagliflozine, metformin – cf. Nevertheless, Framed) are now refundable (65 %) [1]. In addition, approved to communities [2] in a pediatric population, in children 10 years and overfor the treatment of Type 2 diabetes, In addition to a diet et of a physical activity :
- in patients who are insufficiently controlled by metformin alone at the maximum tolerated dose;
- In association with insulin, in patients insufficiently controlled by metformin and insulin;
- In patients already treated by the combination of empagliflozine and metformin administered in the form of separate tablets.

. Meanwhile,
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Two Synjardy specialties are marketed in France:
Synjardy is indicated in adults and children aged 10 and over for the treatment of type 2 diabetes, in addition to a diet and physical activity:
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Synjardy in children: a reimbursement perimeter slightly different from the indication of the AMM – Synjardy now refundable children
Synjardy obtained an extension of its marketing authorization (AMM) in children in 2024, while it was previously limited to synjardy now refundable children adults.
In his April 2025 advice [3]the Transparency Commission (CT) issued an opinion favorable to the care of Synjardy in children. but within a more limited use perimeter than that provided by the AMM (cf. Framed).
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- She attributed a MEDICAL MEDICAL SERVICE (SMR) IMPORTANT Only in the treatment of children aged 10 and over with type 2 diabetes in addition to a diet and physical activity:
- In patients who are insufficiently controlled by metformin alone at the maximum tolerated dose,
- In combination with insulin, in patients insufficiently controlled by metformin and insulin,
- In patients already treated by the combination of empagliflozine and metformin administered in the form of separate tablets. As a reminder. empagliflozine medication alone jardiance (jardiance 10 mg and 25 mg) is already refundable in children 10 years and over, dual therapy with metformin or tritherapy with metformin and insulin. Metformin alone is also refundable in synjardy now refundable children children 10 years and over.

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- However, the SMR was deemed insufficient When Synjardy is used in combination with other drugs intended for the treatment of diabetes, except insulin and Metfomine.
Dose recommendations in pediatrics
Synjardy’s dosage must be adapted to the patient according to his current treatment, his effectiveness and his tolerance:
- Adding empagliflozine to a treatment with metformin :
- The dose of metformin must remain the same,
- The recommended initial dose of empagliflozine is 5 MG twice a day (total daily dose of 10 mg). In patients who tolerate empagliflozine in a dose of 5 MG 2 times a day. which require better glycemic control, the dose can be increased to 12.5 MG twice a day (total daily dose of 25 mg)

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- prescription de SYNJARDY In relay of empagliflozine and metformin in the form of synjardy now refundable children distinct tablets: the patient must receive the same daily dose of empagliflozine and metformin or receive the appropriate therapeutic dose of the nearest Metformin.
Synjardy’s maximum daily daily dose is 25 mg of empagliflozine and 2,000 mg of metformin, or 2 jardiance tablets 12.5 mg/1,000 mg per day.
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