New research shows that neurogenesis slows down at the start of adulthood, an impact on memory

Age often brings a gradual drop in the ability to learn new things and keep memories. Similarly, This phenomenon. Therefore, often associated with the elderly, is linked to the brain deterioration capacity to generate new neurons – a process that occurs mainly in the hippocampus – such as neural stem cells (NSC) divide and mature. For example, Recent research suggests that this decline begins much earlier in life than we thought before. Similarly, potentially starting at the beginning of adulthood.

Although it is established that the overall decrease in brain function is associated with the decrease in NSCs. Moreover, precise underlying molecular changes and their deadlines remain vague. However, Changes in epigenetic changes that affect the expression of genes without modifying the crucial roles of DNA sequence sequence in cell aging. However, new research shows neurogenesis slows but their impact on NSCs remains unknown.

In this vein. Similarly, a research team including Shuzo Matsubara, Kanae Matsuda-Ito, Haruka Sekiryu, Hiroyoshi Do, Takumi Nakagawa and Kinichi Nakashima from the University of Kyushu, Naoya Murao of the University of Miyazak, and Hisanobu Oda of Saiseikai Taito Matsuda Neural and cerebral repair at the Nara Institute of Sciences and Technology (Naive), in Japan, has decided to discover early aging processes in NSC. Their study was made available online on June 3, 2025 and published on July 01, 2025, in volume 44, number 13 The Journal Embo.

The researchers used monocellular sequencing techniques to analyze the expression of genes in NSCs. newly generated neurons through different stages of life in mice. This allowed them to map the key molecular changes that the NSCs suffer from birth to the beginning of adulthood. as well as the corresponding alterations of their ability to produce new research shows neurogenesis slows new neurons.

A key discovery was linked to a gene called Setd8which controls the addition of a chemical label (molecule) on. DNA racking proteins called histones. Researchers discovered that Setd8 have shown a marked decrease in expression as the brain aged. In turn. this reduction in Setd8 The levels were directly linked to the activity and the proliferation of altered NSCs, as well as notable problems in memory in mice. The team has also shown that the artificial decline Setd8 The levels have imitated various molecular signatures of aging NSCs. which suggests that it could be a critical biomarker of early aging.

Overall. the results highlight the unknown role of Setd8 In NSC aging, which has strong implications from a biomedical point of view.

« Understanding how SETD8 affects the aging of neural stem cells opens up the possibility of developing new therapies to slow down. reverse early brain new research shows neurogenesis slows aging. This could help preserve memory. learning capacities, and could lead to future treatments for age -related conditions such as Alzheimer’s disease. This is aligned with the research of our laboratory on cell reprogramming technologies. which, in our view, could make it possible to “rejuvenate” the aged and functioning cells. «

Taito Matsuda, Associate Professor, Laboratory for Neural Regeneration and Brain Repair, Nara Institute of Science and Technology

Although other efforts are necessary to translate these results into therapeutic solutions and in clinical practice, Dr. Matsuda is looking forward to continuing this exciting research line. “” I am deeply honored to be able to advance research from research to naive. where Professor Shinya Yamanaka launched his revolutionary work on the multi -sided stem cells induced induced“He concludes.