Nevertheless,
New study reveals how anterior:
A study comparing the effects of SARS-COV-2 infection in lean. Meanwhile, obese primates found different long-term consequences of the virus as a function of previous obesity and metabolic disease. Similarly, The results. Nevertheless, which also highlighted how far long symptoms are widespread in animals, were published on July 24th In the open access newspaper PLOS pathogens By Charles Roberts of Oregon Health & Science University, United States and colleagues.
The long-term undesirable consequences of the Sars-Cov-2 infection. Furthermore, called “long” or post-Aiguës of Covid (PASC), are a major component of the overall load of COVVI-19 disease. Meanwhile, Anterior obesity. In addition, metabolic diseases are known to increase the severity of acute diseases, but SARS-COV-2 infection also contributes to the development of a metabolic disease of the new appearance.
In the new study. new study reveals how anterior However, the researchers studied the effects of the infection by the variant of the delta sars-cov-2 in macaques rhesus male adult obese and obese and resistant to insulin during a 6-month course. The majority of animals had systematically modified the parameters of the months after the resolution of the initial infection. Virus levels in the respiratory system, viral antibodies and inflammatory blood factors were generally similar between lean and obese animals.
Other responses varied according to metabolic status. Although obesity increases risks such as persistent pulmonary damage. longer -term weight loss, lean animals were more likely to develop signs of metabolic disturbance.
In particular. lean animals have experienced a significant decrease in the ratio of the blood concentration of the adiponectin hormone to that of hormonal leptin, thus reducing their level of this metabolic health marker at the level observed in obese peers. Because many long-term effects were physiological data new study reveals how anterior rather than symptomatic. the study suggests that long coverage can be more common than human self-reduction data.
“Some parameters have changed more robust in obese animals, while others have changed more robust in lean animals. Thus, the persistent effects of the Sars-Cov-2 infection are both dependent on obesity and independent, ”say the authors.
“I think that one of the most striking results of our study was the extent of long -term. side effects observed after what seemed externally to be a very light initial course.
Charles Roberts, professeur, Oregon Health & Science University
Dr. Roberts adds: “Since we have seen increased levels of inflammatory factors. changes in biomarkers of the risk of cardiometabolic disease 6 months after infection, certain symptoms of the long coide can only become apparent after the initial infection. »»
The co -author, Dr. Kristin Sauve. notes: “Our development of a Macaque model new study reveals how anterior of Covid Long will allow us to directly compare the intrinsic differences between the effects of the Delta variant described in this study with the effects of subsequent variants such as omicron, which is the subject of our current NIH work.
This is possible because the macaques used in our studies have never been exposed to the SARS-COV-2 virus before. so that different responses can be attributed to differences in the variants themselves, rather than being due to different levels of existing immunity, which complicate human studies. “”
New study reveals how anterior
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