Retain
- The combination of vitamin D supplementation and physical exercise significantly improves carbohydrate metabolism, reducing blood sugar (p = 0.0218), fasting insulin (p <0.0001) and the Homa-IR index (p <0.0001).
- This combined approach also increases the levels of 25 (OH) D (p = 0.0389) and improves lipid profile more efficiently than each intervention alone.
Methodology
- A systematic meta-analysis was carried out on 18 randomized clinical trials including 1,104 adult participants, assessing the effects of vitamin D supplementation combined with exercise on glucolipid metabolism and levels of 25 (OH) d.
- Researchers have research in 3 databases (Medline, Embase, Web of Science) up to 1is May 2025, using specific inclusion criteria for randomized controlled trials.
- The methodological quality of studies has been evaluated using the tool Cochrane Risk of Bias 2 And the effects of the treatment were analyzed using models with fixed/random effects with the G of Hedges for the effect sizes.
- The interventions included vitamin D supplementation (400 IU to 8,000 IU per day) combined with the financial year, over periods ranging from 4 weeks to 18 months, with appropriate control groups.
Main results
- The vitamin D-EXERCICE combination has significantly improved the levels of 25 (OH) D (Effective size 4.13 [0,21-8,04] ; p = 0.0389) and reduces blood sugar (G, -2.69 [-4,99 à -0,39] ; p = 0,0218).
- The combined intervention has shown a significant reduction in empty insulin (effective size -1.41 [-1,57 à -1,26] ; P <0.0001) and the Homa -IR index (Effective size -0.64 [-0,79 à -0,50] ; p < 0,0001).
- The triglycerides have been significantly reduced (effective size -0.44 [-0,68 à -0,20] ; p = 0.0003) and the increased HDL-cholesterol (effect size 0.66 [0,01-1,31] ; p = 0.0496) in the combined group compared to the vitamin D group alone.
- According to the authors, the synergistic effect of the combined intervention was maintained up to 12 weeks of follow -up, unlike individual interventions.
In practice
Epidemiological data indicate that between 30 % and 80 % of the world’s population has a vitamin D deficiency, which is correlated with the development of type 2 diabetes and a reduction in insulin secretion. Prospective cohort studies have shown that insufficient vitamin of accelerating the progression of prediabetes to type 2 diabetes, while vitamin D supplementation significantly improves the Homeostasis of glucose. Although the individual effects of exercise and vitamin D supplementation on glucolipidic metabolism have been well studied, the potential synergistic benefits of the combination of these interventions remain uncertain. Hence the interest of this study.
For the authors of this study, ” The combination of vitamin D supplementation and exercise has proven to improve glucolipid metabolism more effectively than each intervention alone ».
Main limitations
The authors highlight several important limitations of this meta-analysis. Due to the limited size of the samples of the studies included, some lack of sufficient details for a precise qualitative assessment. The analysis does not include an in -depth examination of the dosage of vitamin D and exercise parameters (frequency, duration, intensity), which limits the complete understanding of the impact of the combined intervention regime. In addition, the use of basic drugs by participants may have masked the subtle effects of vitamin D and the potential impacts of antidiabetic drugs, insulin therapy and dyslipidemia should be taken into account.
This article was created using several editorial tools, including AI, as part of the process. The editorial team saw this content before its publication.
