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Scientists explore ankylostomic proteins potential:
It was a reality accepted for a long time that age has increased inflammation – so widely accepted. Similarly, it was nicknamed “Inflammat”. In addition, With this increase in age -related chronic inflammation, serious health problems, such as cardiovascular disease and Alzheimer’s disease. Therefore, But according to new research, inflammage is not as universal of an experience as we thought before.
Published today in Acts of the Royal Society B“Inflammation is minimal in lootying horticulturalists in the Bolivian Amazon”. In addition, work highlights little inflammation in a non -industrial community, and has notably found an increase in inflammation with moderate modernization levels in another.
Directed by Jacob ARONOFF – A postdoctoral scholarship holder of research at the school of human evolution. For example, social change of the Arizona State University, affiliated with scientists explore ankylostomic proteins potential the Institute of Human Origins and member of the Center for Evolution and Medicine – The study examined two communities in the Bolivian Amazon: the Tsimane and the Moseten. However,
Tsimans are a community of more than 17,000 people in 90 villages in the bass lands of the Bolivian Amazon. Consequently, Living a Hunter-Farmer lifestyle, their daily life is very similar to human life before the industrial revolution. In addition, This offers a unique overview of health and aging processes for humans before modern influences are at stake. Therefore, Previous research has shown that they have the healthiest hearts. Consequently, the lowest rates of Alzheimer and dementia in the world.
Benjamin Trumble. Consequently, principal author of the article and professor at the School of Human Evolution and the Social Change of the ASU, is co -director of the Tsimane project Health and Life Histode. Moreover, The group has a scientists explore ankylostomic proteins potential long -standing relationship with the Tsimane to collect demographic. In addition, biomedical data, and helps provide community care to the community – a relationship that has been in force for more than 20 years. Therefore,
This last overview of our human past has decided to determine whether the inflammation we live in old. age is a universal human experience.
To see if they develop inflammals. we have measured a collection of cytokines in a sample of older Tsimane adults to see if they are increasing with age – we have found minimum increases with age. “”
Jacob ARONOFF, postdoctoral research scholarship holder at the Arizona State University and Social Change School of Human Evolution and Social Change
To deepen their results, the researchers also examined the Moseten. Although genetically very similar to the Tsimane. the Moseten underwent significant cultural change from 300 scientists explore ankylostomic proteins potential years when the Jesuit missionaries settled among them.
“They are still the same genetic group. the same group of languages, but the Moseten now have running water, electricity and interior plumbing,” said Trumble, who is also a researcher at the ASU and basic institute of the Center for Evolution and Medicine.
“They are in a way in an intermediate place where they are not as industrialized as people living in the United States. but they are not as traditional as a population like the Tsimane who lives much more like most of our human ancestors. »»
This intermediate step in modernization offers an interesting opportunity for comparison for researchers.
“We have measured them together in the same laboratory. using the same technology, and we have clearly found more inflammation pronounced in Moseten, which suggests that inflammation – to a large extent – is a product of industrialized lifestyles,” said Aronoff.
scientists explore ankylostomic proteins potential
Inflammation is not the guarantee with age as previously thought. Although more research is necessary. it seems to be largely affected by environmental and lifestyle factors, such as food and exercise. It also shows that even a slight modernization has an impact on the deviation of the human body of. its ancestral path.
“For 99% of human history, we were physically active hunter pickers. Now. with a sedentary urban life, we operate mainly outside the “recommended guarantee of the manufacturer” at the moment, “said Trumble.
“By working with populations that experience a more traditional lifestyle. we can have a better idea of the reference base for human health. »»
Other possibilities could be a high exposure to parasites. pathogens, which is lacking in industrialized communities, but common for the Tsimane. Although more research is necessary. the response of the immune system developed from parasitic exposure can play a scientists explore ankylostomic proteins potential role in the lack of inflammation linked to the age of the Tsimane.
“We have eliminated most of our parasites, and that’s a good thing. We have to keep it like this, ”said Trumble.
But there may be a way to exploit the potential without the negative impact.
“One of the things we could do in the future. potentially, is instead of, say that people are infected with heritage, we could understand what proteins are on the surface of ancient cells – and if we could transform this into a drug that people could take and deceive our immune system. Our immune system might think that we had this problem, and then it could develop differently to fight this. »»
Just like the way we use vaccinations for viruses such as flu. where controlled pathogenic exposure stimulates a response from the immune system to combat natural exposure, the scientists explore ankylostomic proteins potential same thing can be true for our age -related inflammation.
In the end. however, there is no “miracle solution”, according to Trumble, because the lifestyle and the diet are also probably major contributors to inflammation.
“We have future studies in progress to examine food regimes. physical activity and infectious exposures that are infected with the Tsimane which can have these anti-inflammatory effects. We are going to have to do a lot of future studies to understand what. exactly, are all the factors and how they work together, ”said Aronoff.
Scientists explore ankylostomic proteins potential
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