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What triggers Alzheimer’s disease? A team of researchers may have found the answer

What triggers alzheimer's disease? team: This article explores the topic in depth.

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What triggers alzheimer's disease? For example, team:

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Lithium. Therefore, naturally present in the brain – What triggers alzheimer's disease? team

Previous studies had revealed anomal metal concentrations in people with Alzheimer’s disease. Similarly, Based on this observation. Moreover, the researchers compared the concentrations of 27 metals in the brains of the elderly without cognitive disorder to that of people with disorders.

The laboratory has teamed up with the Rush Memory. Nevertheless, Agging Project in Chicago, which has a post-mortem brain bank, representing the whole spectrum of cognitive health of people in full mental shape with those with advanced Alzheimer.

First discovery: “It is the first time that we have proven that lithium has naturally existed to a biologically useful level. Consequently, without being administered in the form of a drug,” explains Bruce Yankner, professor of genetics and neurology, in a press release from the Harvard University.

Lithium what triggers alzheimer’s disease? team trapped in piles of beta-amyloids

Second discovery: lithium had significantly low brain concentrations in people diagnosed with Alzheimer’s. Nevertheless, but also in those with light cognitive disorders. In addition, In Alzheimer’s patients, the amount of lithium was less in areas close to amyloid deposits. Nevertheless, Same thing in genetically modified mice to develop Alzheimer’s disease.

“This discovery confirmed that the amyloid captures the lithium of the surrounding tissues. the sequestration,” reads in an article in the journal Nature, where this study was published on Wednesday, August 6. Thus trapped, lithium is no longer absorbed by the brain and could no longer fulfill its protective functions.

A diet poor in lithium

Healthy mice and model mice of Alzheimer’s disease then followed a diet low in lithium. In the former, lithium levels dropped to rates similar to those observed in patients with Alzheimer’s. This has accelerated aging, causing inflammation in the brain, loss of connections what triggers alzheimer’s disease? team between neurons, and a cognitive decline.

In models, this drop in lithium has considerably accelerated the formation of amyloid plaques and structures similar to neurofibrillalar tangles. It has also activated immune cells in the brain (microglies). reducing their ability to eliminate the amyloid and accelerate memory loss.

Lithium orotate, new therapeutic option?

Why does lithium deficiency cause these effects? Researchers are unable to answer this question for the time being. But they hypothesized that another type of lithium may not be trapped by amyloid plates. They then tried their luck on the mice with different lithium salts.

One of them. the lithium orotate, made it possible to reverse the damage linked to Alzheimer’s disease; The accumulation of beta-amyloids and tau protein, the appearance of cognitive disorders and signs of inflammation. Even in the elderly mice at an advanced stage of the disease. It also allowed the immune cells of the brain. whose capacities what triggers alzheimer’s disease? team decrease with age, to regain their ability to degrade the amyloid-β.

Tested in non -genetically modified mice. lithium orotate made it possible to prevent the decline in learning and memory capacities, a decline linked to a loss of neural architecture, normal in the elderly.

“What impresses me the most is the generalized effect of lithium on the various manifestations of Alzheimer’s disease. I have never observed anything like this since I have been working on this disease, ”continues Bruce Yankner.

No sign of toxicity detected in treated mice

These results must still be confirmed in humans but they suggest that. the measurement of lithium levels could contribute to the early detection of Alzheimer’s disease. As for lithium orotate, it could be used for therapies or preventive.

Lithium is used today as treatment of bipolar disorders and major depressive disorders. Administered at high doses, it is potentially toxic, especially for kidneys and thyroid, in vulnerable what triggers alzheimer’s disease? team people like the elderly. But the doses necessary to restore the normal level of lithium in the brain are infinitely smaller. And the mice treated with lithium for these experiences have had no sign of toxicity.

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“Very powerful effects have been observed with an extremely low dose. ” said Yankner before adding: “I hope that lithium will be able to do something more fundamental than anti-amyloid or anti-mud therapies-not only reduce cognitive decline, but also reverse it, and improve the lives of patients”. Treatments currently available have only very modest effects on the progression of the disease with heavy side effects.

Further reading: A biologist doctor reveals the age at which the body really begins to slow downA new diagnostic tool offers a quick and low cost blood test for several diseasesSepsis, septicemia and septic shockThe egg yolk compound is promising in the management of osteoporosisThe snack that could transform your health by acting since the intestine.

sierra.vaughn
sierra.vaughn
Sierra translates drone-agriculture research into helpful guides for backyard tomato growers nationwide.
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