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Microbiota, weapon early screening?:
The current colorectal cancer screening processes have certain limits: the occult blood search test in the stool is not very specific. For example, colonoscopy is invasive.
This is why the identification of new markers. Nevertheless, reliable and non -invasive, can be extremely useful for improving early detection programs. However, The evidence obtained in recent years support the idea that the dysbiosis of the intestinal microbiota accompanies colorectal cancer. suggest that these changes can even be the cause. The intestinal microbiota interacts with food nutrients. which could contribute to the development of colorectal cancer screening programs, provided that a specific microbiological signature can be assigned to it.
In this study152 patients who obtained a positive result in the test to test the occult blood in the stool were selected. then underwent a colonoscopy. Six adenocarcinomas and 123 polyps microbiota, weapon early screening? were detected, while 23 people had no pathological anomaly. The microbiota was then analyzed by metagenomics of the 16S.
These data were used to design statistical models aimed at assessing the potential of the intestinal microbiota. alone or in combination with food, as a biomarker allowing to differentiate individuals with lesions associated with colorectal cancer (polyps or adenocarcinomas) from those with no pathological anomaly.
The results suggest that the interaction between microbiota and eating habits is relevant when used as a cancer marker. The area under the curve of the microbiota model was 0.79; That of the food -based model, 0.71; and that of the combined model reached 0.80. Furthermore. the presence of species Suterella, Oscillospirales, Proteobacteria et Burkholderiales turned out to be highly discriminating between the groups, as well as the microbiota, weapon early screening? consumption of fruits and vegetables as well as that of soft and/or sweet drinks.
Although the combination of the intestinal microbiota. eating habits have not improved the performance of the model, the results nevertheless suggest that the microbiota profile associated with colorectal cancer depends on some of these food behaviors as well as on the specific composition of this microbiota.
This article has been translated fromUnivadis.es. The content was reviewed by the editorial staff before publication.
Microbiota, weapon early screening?
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